Document Detail

Eating, drinking and temperature responses to intracerebroventricular cholecystokinin in the chick.
MedLine Citation:
PMID:  6294630     Owner:  NLM     Status:  MEDLINE    
The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. Four-week old chicks were maintained in a thermoneutral environment of 23-24 degrees C. After food was removed for a 24 hr interval, CCK was infused in a volume of 10.0 microliters into the lateral cerebral ventricle (ICV) in doses ranging from 10-150 ng. Although lower doses of CCK had no effect on food intake, 100 or 150 ng of CCK significantly reduced consumption of food in a dose-dependent manner; water drinking was significantly decreased by 100 ng of CCK. In addition, CCK at doses of 100 and 150 ng prevented the slow rise in Tc observed following infusions of control CSF. This latter effect appeared to be a result of feeding activity associated with caloric intake and the heat increment in the control birds rather than a specific thermoregulatory effect. Overall, our results suggest that CCK may comprise a part of the central mechanism underlying the neural control of short term satiety in an avian species similar to that proposed for the mammal.
D M Denbow; R D Myers
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  3     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1982 Sep-Oct
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  739-43     Citation Subset:  IM    
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MeSH Terms
Appetite Depressants / pharmacology*
Body Temperature / drug effects
Body Temperature Regulation / drug effects*
Cholecystokinin / pharmacology*
Drinking Behavior / drug effects*
Feeding Behavior / drug effects*
Peptide Fragments / pharmacology*
Reg. No./Substance:
0/Appetite Depressants; 0/Peptide Fragments; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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