Document Detail

Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
MedLine Citation:
PMID:  1384305     Owner:  NLM     Status:  MEDLINE    
Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects. To confirm these data over a longer period of observation and to verify whether adherence to dietary restriction could be improved by 5-HTP, 20 obese patients were randomly assigned to receive either 5-HTP (900 mg/d) or a placebo. The study was double-blinded and was for two consecutive 6-wk periods. No diet was prescribed during the first period, a 5040-kJ/d diet was recommended for the second. Significant weight loss was observed in 5-HTP-treated patients during both periods. A reduction in carbohydrate intake and a consistent presence of early satiety were also found. These findings together with the good tolerance observed suggest that 5-HTP may be safely used to treat obesity.
C Cangiano; F Ceci; A Cascino; M Del Ben; A Laviano; M Muscaritoli; F Antonucci; F Rossi-Fanelli
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  56     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-11-19     Completed Date:  1992-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  863-7     Citation Subset:  AIM; IM    
3rd Department of Internal Medicine, University of Rome, La Sapienza, Italy.
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MeSH Terms
5-Hydroxytryptophan / therapeutic use*
Dietary Carbohydrates / administration & dosage
Dietary Proteins / administration & dosage
Energy Intake
Hydroxyindoleacetic Acid / urine
Hyperphagia / drug therapy*
Obesity / diet therapy,  drug therapy*
Weight Loss
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Proteins; 54-16-0/Hydroxyindoleacetic Acid; 56-69-9/5-Hydroxytryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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