Document Detail


Early weaning and prolonged nursing induce changes in cell proliferation in the gastric epithelium of developing rats.
MedLine Citation:
PMID:  11015495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food deprivation stimulates cell proliferation in the gastric epithelium of suckling, but not weanling rats. This study was designed to investigate the role of diet on proliferation in developing animals, using early weaning and prolonged nursing models. Rat pups were subjected to these dietary conditions at d 15 and were killed 3 or 7 d afterwards. One day before killing, half of pups were deprived of food. Body weights were recorded. After mitosis blockade, the histologic sections of the stomach were used for the evaluation of cell proliferation and methapasic cell distribution along the gland, and for the measurement of mucosa thickness. Body weight was impaired at 18 d by early weaning and at 22 d by prolonged nursing. Food restriction promoted a 10-15% weight loss regardless of dietary conditions. At 18 d, food deprivation inhibited cell division (P: < 0.01) and reduced the thickness of the mucosa (P: < 0.05) in rats that were weaned early. At 22 d, only the thickness of the mucosa was different between the groups that were subjected to early weaning and prolonged nursing (P: < 0.05), regardless of feeding state. The frequency of dividing cells along the gland was affected by early weaning in 18- and 22-d-old rats. These results suggest the following: 1) food deprivation effects are dependent on dietary condition at 18 d because different proliferative responses were achieved after early weaning and prolonged nursing; 2) the lack of changes after dietary manipulation in 22-d-old rats indicates a nonresponsive period during postnatal development. We conclude that milk is a modulatory factor for cell proliferation in the gastric mucosa of rats.
Authors:
P Gama; E P Alvares
Related Documents :
7100065 - Effect of feed and water deprivation on organ and blood characteristics of young turkeys.
12730075 - Food hoarding is increased by food deprivation and decreased by leptin treatment in syr...
14491005 - Food satiation in the pigeon.
6131835 - Effect of starvation on enzymes related to lipid metabolism in guinea-pig lungs.
7400485 - Impact of efnep on some nutrition-related practices. developing a tool to record changes.
21158965 - Validation of a culturally appropriate quantitative food frequency questionnaire for in...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  130     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-25     Completed Date:  2000-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2594-8     Citation Subset:  IM    
Affiliation:
Department of Histology and Embryology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Cell Division*
Epithelial Cells / cytology
Female
Food Deprivation
Gastric Mucosa / anatomy & histology
Lactation*
Metaphase
Rats
Rats, Wistar
Stomach / cytology*,  growth & development*
Weaning*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intake of soy products is associated with better plasma lipid profiles in the Hong Kong Chinese popu...
Next Document:  Fermentation by gut microbiota cultured in a simulator of the human intestinal microbial ecosystem i...