Document Detail


Early versus late hCG administration to trigger ovulation in mild stimulated IUI cycles: a randomized clinical trial.
MedLine Citation:
PMID:  22743137     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To verify non-inferiority of the clinical pregnancy rate of Early hCG administration (leading follicle sizes within 16.0-16.9mm in diameter) compared to Late hCG administration (leading follicle sizes within 18.0-18.9mm in diameter). STUDY DESIGN: Prospective randomized trial. Six hundred and twelve infertile women candidates for intrauterine insemination (IUI) received HP-hMG 75IU/day SC from cycle days 4 to 8 and then as per ovarian response. Ovulation was randomly triggered (hCG 5000IU, IM) when the leading follicle diameter ranged between either 16.0 and 16.9mm (Early hCG group, n=227) or 18.0 and 18.9mm (Late hCG group, n=207) and IUI was performed approximately 36h later. RESULTS: Whereas population and sperm characteristics were comparable in both groups, the number of follicles ≥14mm in diameter (P<0.007) and serum estradiol levels (P<0.001) on the day of hCG were lower in the Early versus the Late hCG groups. Clinical (11.9% versus 12.1%) and ongoing (11.0% versus 8.6%) pregnancy rates per randomized women were similar in the two groups and statistical non-inferiority of clinical and ongoing pregnancy rates was demonstrated. CONCLUSION: These results suggest that hCG administered when the largest follicle size reaches 16.0-16.9mm leads to similar clinical and ongoing pregnancy rates as when it reaches 18.0-18.9mm in IUI cycles.
Authors:
Ana Luisa B da Silva; Elisangela Arbo; Renato Fanchin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-26
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  -     ISSN:  1872-7654     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
AP-HP, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, F-92141, France.
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