| Early versus late hCG administration to trigger ovulation in mild stimulated IUI cycles: a randomized clinical trial. | |
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MedLine Citation:
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PMID: 22743137 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To verify non-inferiority of the clinical pregnancy rate of Early hCG administration (leading follicle sizes within 16.0-16.9mm in diameter) compared to Late hCG administration (leading follicle sizes within 18.0-18.9mm in diameter). STUDY DESIGN: Prospective randomized trial. Six hundred and twelve infertile women candidates for intrauterine insemination (IUI) received HP-hMG 75IU/day SC from cycle days 4 to 8 and then as per ovarian response. Ovulation was randomly triggered (hCG 5000IU, IM) when the leading follicle diameter ranged between either 16.0 and 16.9mm (Early hCG group, n=227) or 18.0 and 18.9mm (Late hCG group, n=207) and IUI was performed approximately 36h later. RESULTS: Whereas population and sperm characteristics were comparable in both groups, the number of follicles ≥14mm in diameter (P<0.007) and serum estradiol levels (P<0.001) on the day of hCG were lower in the Early versus the Late hCG groups. Clinical (11.9% versus 12.1%) and ongoing (11.0% versus 8.6%) pregnancy rates per randomized women were similar in the two groups and statistical non-inferiority of clinical and ongoing pregnancy rates was demonstrated. CONCLUSION: These results suggest that hCG administered when the largest follicle size reaches 16.0-16.9mm leads to similar clinical and ongoing pregnancy rates as when it reaches 18.0-18.9mm in IUI cycles. |
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Authors:
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Ana Luisa B da Silva; Elisangela Arbo; Renato Fanchin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-26 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: - ISSN: 1872-7654 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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AP-HP, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, F-92141, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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