Document Detail

Early vasoreactive profile of skeletonized versus pedicled internal thoracic artery grafts.
MedLine Citation:
PMID:  12658207     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: No data are available on the early vasoreactive profile of skeletonized internal thoracic artery grafts. METHODS: Fifteen patients undergoing primary isolated coronary artery bypass grafting were randomly assigned to receive a skeletonized or pedicled internal thoracic artery graft. On the second postoperative day all patients were subjected to follow-up angiography and endovascular infusion of serotonin, acetylcholine, and isosorbide dinitrate. RESULTS: Internal thoracic artery grafts were widely patent in all cases. Mean diameters of the internal thoracic artery were 1.95 +/- 0.17 mm in the pedicled group and 2.26 +/- 0.40 mm in the skeletonized group. After serotonin challenge, mean internal thoracic artery diameters were reduced to 1.44 +/- 0.34 mm and 1.64 +/- 0.14 mm, respectively; acetylcholine challenge lead to a moderate degree of vasoconstriction (1.55 +/- 0.59 mm in the pedicled group and 1.84 +/- 0.15 mm in the skeletonized group). No statistically significant difference was evident between the two groups at any step. CONCLUSION: Skeletonization does not affect the early vasoreactive profile of internal thoracic artery grafts used for surgical myocardial revascularization.
Mario Gaudino; Carlo Trani; Franco Glieca; Mario Attilio Mazzari; Stefano Rigattieri; Giuseppe Nasso; Francesco Alessandrini; Giovanni Schiavoni; Gianfederico Possati
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  125     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  638-41     Citation Subset:  AIM; IM    
Department of Cardiac Surgery, Catholic University, Rome, Italy.
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MeSH Terms
Acetylcholine / pharmacology
Coronary Angiography
Dissection / adverse effects,  methods*
Internal Mammary-Coronary Artery Anastomosis / methods*
Isosorbide Dinitrate / pharmacology
Middle Aged
Serotonin / pharmacology
Surgical Flaps*
Thoracic Arteries / drug effects,  physiopathology*,  radiography,  transplantation*
Tissue and Organ Harvesting / adverse effects,  methods*
Treatment Outcome
Vascular Patency
Vasoconstriction* / drug effects
Vasodilation* / drug effects
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 50-67-9/Serotonin; 51-84-3/Acetylcholine; 87-33-2/Isosorbide Dinitrate

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