| Early vasoreactive profile of skeletonized versus pedicled internal thoracic artery grafts. | |
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MedLine Citation:
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PMID: 12658207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: No data are available on the early vasoreactive profile of skeletonized internal thoracic artery grafts. METHODS: Fifteen patients undergoing primary isolated coronary artery bypass grafting were randomly assigned to receive a skeletonized or pedicled internal thoracic artery graft. On the second postoperative day all patients were subjected to follow-up angiography and endovascular infusion of serotonin, acetylcholine, and isosorbide dinitrate. RESULTS: Internal thoracic artery grafts were widely patent in all cases. Mean diameters of the internal thoracic artery were 1.95 +/- 0.17 mm in the pedicled group and 2.26 +/- 0.40 mm in the skeletonized group. After serotonin challenge, mean internal thoracic artery diameters were reduced to 1.44 +/- 0.34 mm and 1.64 +/- 0.14 mm, respectively; acetylcholine challenge lead to a moderate degree of vasoconstriction (1.55 +/- 0.59 mm in the pedicled group and 1.84 +/- 0.15 mm in the skeletonized group). No statistically significant difference was evident between the two groups at any step. CONCLUSION: Skeletonization does not affect the early vasoreactive profile of internal thoracic artery grafts used for surgical myocardial revascularization. |
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Authors:
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Mario Gaudino; Carlo Trani; Franco Glieca; Mario Attilio Mazzari; Stefano Rigattieri; Giuseppe Nasso; Francesco Alessandrini; Giovanni Schiavoni; Gianfederico Possati |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 125 ISSN: 0022-5223 ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-26 Completed Date: 2003-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 638-41 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiac Surgery, Catholic University, Rome, Italy. mgaudino@tiscalinet.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Aged Coronary Angiography Dissection / adverse effects, methods* Female Humans Internal Mammary-Coronary Artery Anastomosis / methods* Isosorbide Dinitrate / pharmacology Male Middle Aged Serotonin / pharmacology Surgical Flaps* Thoracic Arteries / drug effects, physiopathology*, radiography, transplantation* Tissue and Organ Harvesting / adverse effects, methods* Treatment Outcome Vascular Patency Vasoconstriction* / drug effects Vasodilation* / drug effects Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 50-67-9/Serotonin; 51-84-3/Acetylcholine; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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