Document Detail

Early use of inhaled corticosteroids in infancy.
MedLine Citation:
PMID:  16263466     Owner:  NLM     Status:  MEDLINE    
The inability to accurately predict the outcome of infants with recurrent wheezy bronchitis makes the early use of inhaled corticosteroids (ICS) controversial. Data from bronchoalveolar lavages and epidemiological surveys suggest a persistent inflammation of the airways in the more severe cases. Prospective studies, mostly with nebulized corticosteroids, have demonstrated clinical efficacy on daytime and nightime symptoms, reduced requirements for rescue bronchodilators and a real steroid sparing effect. In infants with episodic viral-associated wheeze with or without interval symptoms, ICS use carries the risk of overtreatment and of adverse effects. Long-term prospective studies are urgently required to assess the efficacy and safety of ICS and their possible effects on the natural history of infantile asthma.
J Blic; P Scheinmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Paediatric respiratory reviews     Volume:  1     ISSN:  1526-0542     ISO Abbreviation:  Paediatr Respir Rev     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2005-12-13     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  100898941     Medline TA:  Paediatr Respir Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  368-71     Citation Subset:  IM    
Hôpital des Enfants Malades, 149 rue de Sèvres, Paris, 75015, France.
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MeSH Terms
Administration, Inhalation
Adrenal Cortex Hormones / administration & dosage*
Age Factors
Asthma / drug therapy
Bronchitis / complications,  drug therapy
Bronchopulmonary Dysplasia / drug therapy
Drug Administration Schedule
Infant, Newborn
Respiratory Sounds / etiology
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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