| Early use of inhaled corticosteroids in infancy. | |
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MedLine Citation:
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PMID: 16263466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inability to accurately predict the outcome of infants with recurrent wheezy bronchitis makes the early use of inhaled corticosteroids (ICS) controversial. Data from bronchoalveolar lavages and epidemiological surveys suggest a persistent inflammation of the airways in the more severe cases. Prospective studies, mostly with nebulized corticosteroids, have demonstrated clinical efficacy on daytime and nightime symptoms, reduced requirements for rescue bronchodilators and a real steroid sparing effect. In infants with episodic viral-associated wheeze with or without interval symptoms, ICS use carries the risk of overtreatment and of adverse effects. Long-term prospective studies are urgently required to assess the efficacy and safety of ICS and their possible effects on the natural history of infantile asthma. |
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Authors:
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J Blic; P Scheinmann |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Paediatric respiratory reviews Volume: 1 ISSN: 1526-0542 ISO Abbreviation: Paediatr Respir Rev Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2005-11-02 Completed Date: 2005-12-13 Revised Date: 2009-10-14 |
Medline Journal Info:
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Nlm Unique ID: 100898941 Medline TA: Paediatr Respir Rev Country: England |
Other Details:
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Languages: eng Pagination: 368-71 Citation Subset: IM |
Affiliation:
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Hôpital des Enfants Malades, 149 rue de Sèvres, Paris, 75015, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adrenal Cortex Hormones / administration & dosage* Age Factors Asthma / drug therapy Bronchitis / complications, drug therapy Bronchopulmonary Dysplasia / drug therapy Drug Administration Schedule Humans Infant Infant, Newborn Respiratory Sounds / etiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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