Document Detail

Early twenty-four-hour blood pressure elevation in subjects with parental hypertension.
MedLine Citation:
PMID:  2632747     Owner:  NLM     Status:  MEDLINE    
We studied 15 normotensive offspring of hypertensive parents, comparing them with 15 normotensive controls matched for sex, body mass index and age. In the offspring, both parents were hypertensive, while in the controls, neither parent was hypertensive. Blood pressure was measured at rest, during a variety of laboratory stressors (mental arithmetic, mirror drawing test, hand grip and cold pressor test), and was also monitored for 24 h in ambulatory conditions (Spacelabs 5300 M, Richmond, Washington, USA). Resting mean and diastolic blood pressures were higher (P less than 0.05) in the subjects with parental hypertension than in those without. The mean blood pressure rise induced by the laboratory stressors was not significantly greater at any time in the subjects with hypertensive parents compared with controls. Twenty-four-hour systolic and mean blood pressures, however, were significantly higher (P less than 0.05) in the subjects with hypertensive parents than in the controls. Thus the higher office blood pressure shown in the prehypertensive stage by subjects with parental hypertension is not due to hypersensitivity to stress, but represents an early and permanent blood pressure elevation.
G Parati; A Ravogli; S Trazzi; A Villani; E Mutti; A Groppelli; G Mancia
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-05-11     Completed Date:  1990-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S64-5     Citation Subset:  IM    
Cattedra di Semeiotica Medica, Università di Milano, Italy.
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MeSH Terms
Blood Pressure / physiology*
Blood Pressure Monitors
Circadian Rhythm / physiology*
Hypertension / genetics,  physiopathology*
Reference Values
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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