| Early treatment with clarithromycin attenuates rat autoimmune myocarditis via inhibition of matrix metalloproteinase activity. | |
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MedLine Citation:
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PMID: 20350988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Matrix metalloproteinase (MMP) activity is upregulated in the hearts with myocarditis, and its activation contributes to the changes in left ventricular function. A major macrolide antibiotic, clarithromycin (CAM), has many biological functions including MMP regulation. However, little is known about the effect of CAM in myocarditis via MMPs. OBJECTIVE: To clarify the role of MMPs regulated by CAM in the progression of myocarditis. Design CAM was given to experimental rats with autoimmune myocarditis (EAM) from day -7 to day 21 (early treated group, n=6) or from day 1 to day 21 (late treated group, n=6) twice a day. RESULTS: Although the non-treated rats showed blood pressure decline and impaired cardiac function, early CAM treatment prevented this progression. Pathologically, severe myocardial cell infiltration (30.5+/-4.2%) and fibrosis (32.2+/-1.1%) were detected in the non-treated group, while early CAM treatment significantly suppressed these changes (infiltration 6.5+/-0.2%, fibrosis 5.9+/-3.9%). Zymography showed that non-treated EAM resulted in enhanced ventricular activities of MMP-9, while early CAM treatment reduced the alteration. However, late CAM treatment was less effective than the early treatment. CONCLUSIONS: Early CAM treatment is effective to attenuate myocarditis by suppressing MMP-9. |
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Authors:
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Keiichi Hishikari; Ryo Watanabe; Masahito Ogawa; Jun-ichi Suzuki; Mayumi Masumura; Tomoko Shimizu; Kiyoshi Takayama; Yasunobu Hirata; Ryozo Nagai; Mitsuaki Isobe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 96 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 523-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan. junichisuzuki-circ@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / drug therapy* Blood Pressure / drug effects Clarithromycin / pharmacology* Heart Rate / drug effects Immunohistochemistry Male Matrix Metalloproteinases / antagonists & inhibitors* Myocardial Contraction / drug effects Myocarditis / drug therapy* Protein Synthesis Inhibitors / pharmacology* Rats Rats, Inbred Lew |
| Chemical | |
Reg. No./Substance:
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0/Protein Synthesis Inhibitors; 81103-11-9/Clarithromycin; EC 3.4.24.-/Matrix Metalloproteinases |
| Comments/Corrections | |
Comment In:
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Heart. 2010 Apr;96(7):494-5
[PMID:
19617212
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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