| Early treatment of a single generalized tonic-clonic seizure to prevent recurrence. | |
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MedLine Citation:
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PMID: 8912488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The question of whether to start antiepileptic treatment after a single unprovoked seizure remains controversial and has been the subject of much debate in the relevant literature. OBJECTIVES: To determine the rate of recurrence of a second attack after a single unprovoked epileptic seizure by using 2 study groups of treated and untreated patients and, thus, to establish a treatment policy for these patients. PATIENTS AND METHODS: A group of 91 patients with a single generalized tonic-clonic seizure were prospectively studied; 87 of these patients completed the study. The end point of the study was 36 months after the single attack or the occurrence of a subsequent epileptic attack. The patients were randomly divided into 2 groups; 45 patients who immediately received anticonvulsive treatment and 42 who remained untreated for the follow-up period. Patients in the treated group were given monotherapy with carbamazepine. The results of recurrences were statistically analyzed by using the Kaplan-Meier method. RESULTS: Results indicated a significantly higher percentage of seizure-free patients in the treated group compared with that in the untreated group (P = .001). The treated men were proved to be less at risk for recurrent seizures compared with treated women (P < .001 vs P = .03, respectively). CONCLUSION: Treatment after a single unprovoked seizure leads to a significant reduction in the risk of relapse of generalized tonic-clonic epilepsy. |
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Authors:
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R Gilad; Y Lampl; U Gabbay; Y Eshel; I Sarova-Pinhas |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Archives of neurology Volume: 53 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1996-12-20 Completed Date: 1996-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1149-52 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Edith Wolfson Medical Center, Holon, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbamazepine / therapeutic use* Epilepsy, Tonic-Clonic / drug therapy* Female Humans Male Prognosis Recurrence Time Factors |
| Chemical | |
Reg. No./Substance:
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298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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