| Early treatment of avascular necrosis in systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 3740994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Avascular necrosis (AVN) of the hips is associated with significant disability, and the majority of established cases require major surgery. In a retrospective analysis of 185 patients with systemic lupus erythematosus (SLE) 13 (7%) were found to have AVN. Of these, six had Raynaud's phenomenon, all had been on corticosteroids, and one had digital vasculitis. The mean duration of corticosteroid therapy was two years (range four months to five years). Five patients developed AVN two to 10 years after discontinuing steroids. The mean duration of disease at the onset of AVN was 6.85 years (range 1-19 years), and the mean age at onset of AVN was 31 years. Ten patients had severe multisystem involvement. None of the patients abused alcohol. Surgery was performed on 11 hips. Three had total hip replacement for stages 3 and 4 and seven had core decompression for stages 1 and 2. AVN progressed in two (28%) of these patients. In another patient core decompression failed for technical reasons. She subsequently required total hip replacement. The early detection of AVN to avoid the need for major surgery is stressed. |
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Authors:
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A A Kalla; I D Learmonth; P Klemp |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 45 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-09-25 Completed Date: 1986-09-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 649-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenal Cortex Hormones / therapeutic use Adult Age Factors Female Femur Head Necrosis / etiology, surgery* Humans Lupus Erythematosus, Systemic / complications*, drug therapy Middle Aged Raynaud Disease / etiology Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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