| Early treadmill training promotes motor function after hemorrhagic stroke in rats. | |
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MedLine Citation:
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PMID: 20080148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rehabilitation after a stroke is very important because it has beneficial effects on brain function, including the promotion of plasticity. However, an optimal time window for rehabilitation interventions after hemorrhagic stroke has not been clearly defined. The aim of this study was to determine whether early exercise training initiated 24h after an intracerebral hemorrhage (ICH) might enhance neurologic recovery more than exercise initiated 1 week after ICH without hematoma expansion and edema volume increase. We subjected adult male Sprague-Dawley rats to experimental ICH by the intrastriatal administration of bacterial collagenase. The rats were randomly divided into the following 2 groups: early training group (treadmill exercise started 24h post-ICH; n=18) and late training group (treadmill exercise started 1-week post-ICH; n=18). Two weeks after surgery we performed neurologic tests (rota-rod, modified limb-placing, and adhesive-dot removal tests), and measured hematoma volumes and brain water content. In the late training group, compared with the pre-ICH performance on the rota-rod test (98.3+/-69.4s), the animals had significantly worse performance after the post-ICH rehabilitation (40.5+/-52.6s; p<0.01, paired t-test). In the early training group however, the motor performance after the post-ICH rehabilitation (56.4+/-73.5s) was not significantly different from the baseline pre-ICH performance (79.8+/-33.9s; p=0.24). There were no significant differences between the two groups with respect to the other neurologic tests. Early exercise did not increase hematoma size or brain water content. Early treadmill training could be performed safely, and enhanced motor recovery in a rat model of ICH. Further studies are required to translate the results into clinical significance. |
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Authors:
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Jin-Woo Park; Moon-Suk Bang; Bum-Sun Kwon; Yu-Kyung Park; Dae-Whan Kim; Soo-Min Shon; Sang-Wuk Jeong; Dong-Kun Lee; Dong-Eog Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-18 |
Journal Detail:
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Title: Neuroscience letters Volume: 471 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 104-8 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Physical Medicine and Rehabilitation, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Edema / pathology Cerebral Hemorrhage / pathology, physiopathology, rehabilitation* Hematoma / pathology Humans Male Physical Conditioning, Animal* Rats Stroke / pathology, physiopathology, rehabilitation* Time Factors |
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