Document Detail


Early trabecular bone healing around titanium implants: a histologic study in rabbits.
MedLine Citation:
PMID:  17335375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A detailed insight into the early healing response of trabecular bone to unloaded titanium implants is lacking. METHODS: Cylindrical implants were inserted in the tibial epiphysis of rabbits and left to heal for 1 to 42 days. Samples were processed into paraffin or methylmethacrylate sections and histomorphometrically analyzed. RESULTS: A hematoma was observed after 1 and 3 days of implant placement. In addition, small fragments of bone trabeculae were detected around the implant as a result of the implant installment procedure. Soon, osteoclasts were observed resorbing these fragments, whereas osteoblasts incorporated them in strands of new bone, thereby making them difficult to distinguish from day 7 onward. At that time, osteoblasts were detected at the edges of the preexisting bone, actively depositing new bone, resulting in maximal osteoid deposition around the implant after 28 days (58%). After 7 days of healing, the presence of basic remodeling units in the surrounding bone was already maximal (P <0.05 versus t = 1 and 3 days). This remodeling activity, together with the new bone formation, provided a firm anchoring of the implant in the trabecular bone. CONCLUSIONS: This study evaluated the early cellular events in trabecular bone surrounding titanium implants. The insertion of an implant into bone initiates a series of biologic processes, including the formation of a hematoma, shattered bone fragments adjacent to the implantation site, intensive bone remodeling, and the formation of new bone, eventually leading to the osseointegration of the implant.
Authors:
Elke Slaets; Geert Carmeliet; Ignace Naert; Joke Duyck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of periodontology     Volume:  78     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  510-7     Citation Subset:  D; IM    
Affiliation:
Department of Prosthetic Dentistry, BIOMAT Research Group, Catholic University Leuven, Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Nucleus
Dental Implantation, Endosseous
Dental Implants*
Implants, Experimental
Osseointegration*
Osteoblasts / cytology
Osteoclasts / cytology
Rabbits
Statistics, Nonparametric
Tibia
Titanium
Wound Healing
Chemical
Reg. No./Substance:
0/Dental Implants; 7440-32-6/Titanium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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