Document Detail


Early toxicity of recombinant interleukin-2 in cats.
MedLine Citation:
PMID:  1772328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were conducted in cats to determine whether this species could serve as an animal model for the therapeutic toxicity of recombinant interleukin-2 in humans, and to establish the role of the area postrema in the causation of recombinant interleukin-2-induced vomiting. Injections of recombinant interleukin-2 (3.6 x 10(6) IU/kg, i.m.), given once every 24 hr for one to three days, evoked repeated vomiting in 4 out of 6 area postrema intact cats and in 3 out of 3 area postrema-ablated cats. These results suggest that the area postrema is not essential for the emetic action of recombinant interleukin-2. In anesthetized intact cats, no remarkable changes in ventilation, blood pressure, heart rate or blood pH were observed over 4.5 to 54 hr of continuous physiological recording after i.v. injections of recombinant interleukin-2 to a total dose as high as 27 x 10(6) IU/kg. Cat lymphocytes responded appropriately to the cytokinetic action of human recombinant interleukin-2.
Authors:
S F Gonsalves; B E Landgraf; T L Ciardelli; H L Borison
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  310     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1992-02-21     Completed Date:  1992-02-21     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  175-85     Citation Subset:  IM    
Affiliation:
Department of Surgery, Dartmouth Medical School, Hanover, NH 03756.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Carbon Dioxide / blood
Cats
Cell Division / drug effects
Cerebral Ventricles / physiology
Emetics / pharmacology
Female
Heart Rate / drug effects
Hemodynamics / drug effects
Humans
Interleukin-2 / toxicity*
Male
Recombinant Proteins / toxicity
Respiration / drug effects
T-Lymphocytes / drug effects
Time Factors
Grant Support
ID/Acronym/Agency:
ES04063/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Emetics; 0/Interleukin-2; 0/Recombinant Proteins; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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