| Early toxicity of recombinant interleukin-2 in cats. | |
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MedLine Citation:
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PMID: 1772328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were conducted in cats to determine whether this species could serve as an animal model for the therapeutic toxicity of recombinant interleukin-2 in humans, and to establish the role of the area postrema in the causation of recombinant interleukin-2-induced vomiting. Injections of recombinant interleukin-2 (3.6 x 10(6) IU/kg, i.m.), given once every 24 hr for one to three days, evoked repeated vomiting in 4 out of 6 area postrema intact cats and in 3 out of 3 area postrema-ablated cats. These results suggest that the area postrema is not essential for the emetic action of recombinant interleukin-2. In anesthetized intact cats, no remarkable changes in ventilation, blood pressure, heart rate or blood pH were observed over 4.5 to 54 hr of continuous physiological recording after i.v. injections of recombinant interleukin-2 to a total dose as high as 27 x 10(6) IU/kg. Cat lymphocytes responded appropriately to the cytokinetic action of human recombinant interleukin-2. |
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Authors:
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S F Gonsalves; B E Landgraf; T L Ciardelli; H L Borison |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 310 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1991 Mar-Apr |
Date Detail:
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Created Date: 1992-02-21 Completed Date: 1992-02-21 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 175-85 Citation Subset: IM |
Affiliation:
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Department of Surgery, Dartmouth Medical School, Hanover, NH 03756. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Carbon Dioxide / blood Cats Cell Division / drug effects Cerebral Ventricles / physiology Emetics / pharmacology Female Heart Rate / drug effects Hemodynamics / drug effects Humans Interleukin-2 / toxicity* Male Recombinant Proteins / toxicity Respiration / drug effects T-Lymphocytes / drug effects Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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ES04063/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Emetics; 0/Interleukin-2; 0/Recombinant Proteins; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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