Document Detail


Early-to-mid gestation fetal testosterone increases right hand 2D:4D finger length ratio in polycystic ovary syndrome-like monkeys.
MedLine Citation:
PMID:  22927929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A smaller length ratio for the second relative to the fourth finger (2D:4D) is repeatedly associated with fetal male-typical testosterone (T) and is implicated as a biomarker for a variety of traits and susceptibility to a number of diseases, but no experimental human studies have been performed. The present study utilizes the rhesus monkey, a close relative of humans, and employs discrete gestational exposure of female monkeys to fetal male-typical T levels for 15-35 days during early-to-mid (40-76 days; n = 7) or late (94-139 days; n = 7) gestation (term: 165 days) by daily subcutaneous injection of their dams with 10 mg T propionate. Such gestational exposures are known to enhance male-typical behavior. In this study, compared to control females (n = 19), only early-to-mid gestation T exposure virilizes female external genitalia while increasing 2D:4D ratio in the right hand (RH) by male-like elongation of RH2D. RH2D length and 2D:4D positively correlate with androgen-dependent anogenital distance (AG), and RH2D and AG positively correlate with duration of early-to-mid gestation T exposure. Male monkeys (n = 9) exhibit a sexually dimorphic 2D:4D in the right foot, but this trait is not emulated by early-to-mid or late gestation T exposed females. X-ray determined phalanx measurements indicate elongated finger and toe phalanx length in males, but no other phalanx-related differences. Discrete T exposure during early-to-mid gestation in female rhesus monkeys thus appears to increase RH2D:4D through right-side biased, non-skeletal tissue growth. As variation in timing and duration of gestational T exposure alter male-like dimensions of RH2D independently of RH4D, postnatal RH2D:4D provides a complex biomarker for fetal T exposure.
Authors:
Andrew D Abbott; Ricki J Colman; Ross Tiefenthaler; Daniel A Dumesic; David H Abbott
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-22
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-28     Completed Date:  2013-01-29     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e42372     Citation Subset:  IM    
Affiliation:
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin, United States of America. aabbott@primate.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Endocrinology
Female
Fetus / anatomy & histology,  drug effects*
Finger Phalanges / anatomy & histology,  drug effects,  embryology
Fingers / anatomy & histology*,  embryology*
Hand Joints / anatomy & histology,  drug effects,  embryology
Macaca mulatta
Male
Polycystic Ovary Syndrome / pathology*,  physiopathology
Pregnancy
Reproduction / drug effects
Sex Characteristics
Testosterone / pharmacology*
Time Factors
Grant Support
ID/Acronym/Agency:
P51 RR000167/RR/NCRR NIH HHS; R01 RR013635/RR/NCRR NIH HHS; RR020141-01/RR/NCRR NIH HHS; RR15459-01/RR/NCRR NIH HHS; U01 HD044650/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
58-22-0/Testosterone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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