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Early-term Birth (37-38 Weeks) and Mortality in Young Adulthood.
MedLine Citation:
PMID:  23337240     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:: Early-term birth (gestational age, 37-38 weeks) has been associated with increased infant mortality relative to later-term birth, but mortality beyond infancy has not been studied. We examined the association between early-term birth and mortality through young adulthood. METHODS:: We conducted a national cohort study of 679,981 singleton births in Sweden in 1973-1979, followed up for all-cause and cause-specific mortality through 2008 (ages 29-36 years). RESULTS:: There were 10,656 deaths in 21.5 million person-years of follow-up. Among those still alive at the beginning of each age range, early-term birth relative to those born at 39-42 weeks was associated with increased mortality in the neonatal period (0-27 days: adjusted hazard ratio = 2.18 [95% confidence interval = 1.89-2.51]), postneonatal period (28-364 days: 1.66 [1.44-1.92]), early childhood (1-5 years: 1.29 [1.10-1.51]), and young adulthood (18-36 years: 1.14 [1.05-1.24]), but not in late childhood/adolescence (6-17 years: 0.97 [0.84-1.12]). In young adulthood, early-term birth was strongly associated with death from congenital anomalies and endocrine disorders, especially diabetes (2.89 [1.54-5.43]). CONCLUSIONS:: In this large national cohort study, early-term birth was independently associated with increased mortality in infancy, early childhood, and young adulthood. Lowest short-term and long-term mortality was among those born at 39-42 weeks.
Authors:
Casey Crump; Kristina Sundquist; Marilyn A Winkleby; Jan Sundquist
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  -     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the aDepartment of Medicine, Stanford University, Stanford, CA; bCenter for Primary Health Care Research, Lund University, Malmö, Sweden; and cStanford Prevention Research Center, Stanford University, Stanford, CA.
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