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Early subclinical increase in pulmonary water content in athletes performing sustained heavy exercise at sea level: ultrasound lung comet-tail evidence.
MedLine Citation:
PMID:  21873499     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Whether prolonged strenuous exercise performed by athletes at sea-level can produce interstitial pulmonary edema is under debate. Chest sonography allows to estimate extravascular lung water, creating ultrasound lung "comet-tail" (ULC) artifacts. Aim of the study was to determine whether pulmonary water content increases in Ironmen (n=31) during race at sea-level and its correlation with cardiopulmonary function, systemic pro-inflammatory and cardiac bio-humoral markers. . A Multiple Factor Analysis approach was used to determine the relations between systemic modifications and ULCs by assessing correlations among variables and groups of variables showing significant pre-post changes. All athletes were asymptomatic for cough and dyspnea at rest and after the race. Immediately after the race, a score of more than 5 comet tail artifacts, the threshold for a significant detection, was present in 23 athletes (74 %, 16.3 ± 11.2, p<0.01 ULC after the race vs. rest), but decreased 12 h after the end of the race (13 athletes, 42%, 6.3 ± 8.0, p<0.01 vs. soon after the race). Multiple Factor Analysis showed significant correlations between ULCs and cardiac related variables and N-Terminal pro-Brain Natriuretic Peptide (NTproBNP). Healthy athletes developed subclinical increase in pulmonary water content immediately after an ironman race at sea level, as shown by the increased number of ULCs related to cardiac changes occurring during exercise. Hemodynamic changes are one of several potential factors contributing to the mechanisms of ULCs.
Authors:
Alessandro Pingitore; Erika Garbella; Paolo Piaggi; Danilo Menicucci; Francesca Frassi; Vincenzo Lionetti; Angelo Gemignani; Andrea Piarulli; Giosuè Catapano; Walter Lubrano; Mirko Passera; Gianluca Di Bella; Cinzia Castagnini; Silvia Pellegrini; Maria Rosa Metelli; Remo Bedini; Antonio L'abbate
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-26
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Clinical Physiology Institute, CNR.
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