Document Detail


Early statin therapy in elderly patients presenting with acute coronary syndrome causing less heart failure.
MedLine Citation:
PMID:  19039148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Elderly patients are less likely to receive statin therapy because of concerns about their side-effects. However, 80% of deaths related to coronary heart disease occur in patients above the age of 65 years. This study evaluated the potential benefit of early administration of statins in elderly patients presenting with an acute coronary syndrome. METHODS: This was a prospective cohort study of 774 elderly patients (>65 years) with acute coronary syndrome. The patients were divided into two groups. The first group, consisting of 611 patients, received statins within the first 24 hours of admission, while the second group, consisting of 163 patients, received statins after the first 24 hours. The end points studied included death, heart failure/pulmonary edema, stroke and recurrent myocardial infarction during hospitalization. RESULTS: Multivariable logistic regression analysis, adjusting for baseline demographics, co-morbidities and chronic statin therapy, showed that the occurrence of heart failure/pulmonary edema during hospitalization was relatively lower among those who received statins within 24 hours of admission (odds ratio: 0.5, 95% CI: 0.27-0.94, p=0.03). The C statistic for the model was 0.79. CONCLUSION: Elderly patients presenting with acute coronary syndrome seem to benefit from early statin therapy, and have significantly lower rates of heart failure and pulmonary edema than those who are administered statins at a later stage.
Authors:
Fadi A Saab; Mircea Petrina; Eva Kline-Rogers; Jianming Fang; Richard Otten; Debabrata Mukherjee; Kim A Eagle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian heart journal     Volume:  58     ISSN:  0019-4832     ISO Abbreviation:  Indian Heart J     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374675     Medline TA:  Indian Heart J     Country:  India    
Other Details:
Languages:  eng     Pagination:  321-4     Citation Subset:  IM    
Affiliation:
University of Michigan Cardiovascular Center, Ann Arbor, Michigan 48109-0047, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / complications,  drug therapy*
Aged
Aged, 80 and over
Female
Heart Failure / etiology,  prevention & control*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Logistic Models
Male
Prospective Studies
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

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