Document Detail

Early stage vision in schizophrenia and schizotypal personality disorder.
MedLine Citation:
PMID:  16829048     Owner:  NLM     Status:  MEDLINE    
Previous studies of visual perception have reported deficits in contrast sensitivity and dot motion discrimination in schizophrenia. We tested whether these deficits also appear in schizotypal personality disorder (SPD). SPD appears to be genetically and symptomatically related to schizophrenia, but without the marked psychosocial impairment associated with psychotic disorders. The present study investigated contrast sensitivity for moving and static gratings, form discrimination and dot motion discrimination in 24 patients with schizophrenia or schizoaffective disorder (SZ), 16 individuals with SPD, and 40 control subjects. SZ, but not SPD subjects, showed impairments on tests of contrast sensitivity for static and moving gratings, form discrimination in noise, and dot motion discrimination. Visual performance did not differ between medicated SZ patients and patients withdrawn from medication. These results confirm early stage visual deficits in schizophrenia regardless of medication status. SPD subjects, in contrast, show intact early stage visual processing despite the presence of marked schizotypal symptoms.
Brian F O'Donnell; Andrew Bismark; William P Hetrick; Misty Bodkins; Jenifer L Vohs; Anantha Shekhar
Related Documents :
16829048 - Early stage vision in schizophrenia and schizotypal personality disorder.
10507518 - The conflict of the nosologists: views on schizophrenia and manic-depressive illness in...
2436738 - Are schizophreniform symptoms present in attenuated form in children with tourette diso...
10208448 - Environment and vulnerability to major psychiatric illness: a case control study of ear...
18686748 - Treatment of fragile x-associated tremor ataxia syndrome (fxtas) and related neurologic...
17186368 - Factor analysis of the aberrant behavior checklist in individuals with autism spectrum ...
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-07-10
Journal Detail:
Title:  Schizophrenia research     Volume:  86     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2006-12-20     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  89-98     Citation Subset:  IM    
Department of Psychology, Indiana University, Bloomington, IN, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Antipsychotic Agents / therapeutic use
Contrast Sensitivity / physiology
Discrimination (Psychology) / physiology
Middle Aged
Neuropsychological Tests / statistics & numerical data
Photic Stimulation / methods
Psychiatric Status Rating Scales / statistics & numerical data
Reaction Time / physiology
Schizophrenia / drug therapy,  physiopathology*
Schizotypal Personality Disorder / drug therapy,  physiopathology*
Sensory Thresholds / physiology
Statistics as Topic
Vision, Ocular / drug effects,  physiology*
Visual Perception / drug effects,  physiology*
Grant Support
1 R01 MH62150-01/MH/NIMH NIH HHS
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Acute infantile encephalopathy predominantly affecting the frontal lobes (AIEF): a novel clinical ca...
Next Document:  Asymptomatic bacteriuria: review and discussion of the IDSA guidelines.