Document Detail


Early-stage mycosis fungoides variants: case-based review.
MedLine Citation:
PMID:  20850703     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. The diagnosis of classic MF is based on a combination of clinical presentation, histopathology, and T-cell monoclonality detected by molecular studies. However, the diagnosis can be difficult in cases of early MF because of the subtle nature of histologic findings and, in cases of variants of MF, because of the unusual clinical and/or pathologic features. In this review, we presented the most frequent variants of MF at early stage including hypopigmented, folliculotropic, pagetoid reticulosis, unilesional, granulomatous, and ichthyosis forms. This case-based clinicopathologic review provides the notion that a comprehensive clinicopathologic correlation is of substantial importance to render the diagnosis of MF. In addition, we discuss the role of molecular studies, which are highly sensitive and recently more applicable to routinely processed skin biopsy specimens in the diagnosis of MF.
Authors:
Jeong Hee Cho-Vega; Jaime A Tschen; Madeleine Duvic; Francisco Vega
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of diagnostic pathology     Volume:  14     ISSN:  1532-8198     ISO Abbreviation:  Ann Diagn Pathol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800503     Medline TA:  Ann Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  369-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
St Joseph Dermatopathology, Houston, TX 77030, USA. vegaelena@ymail.com
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