| Early-stage BRCA2-linked breast cancer diagnosed in the first trimester of pregnancy associated with a hypercoagulable state. | |
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MedLine Citation:
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PMID: 19777765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This patient was found to have a BRCA2 gene mutation. She underwent lumpectomy and axillary lymph node dissection without any evidence of lymph node metastasis. Systemic chemotherapy with doxorubicin and cyclophosphamide for four cycles was administered beginning in the second trimester. She was treated with prophylactic LMWH until delivery and then for 6 weeks postpartum. She delivered a healthy baby boy and, after a period of breast-feeding, underwent bilateral mastectomy with immediate reconstruction. She remains well and is expecting her second child. Prophylactic oophorectomy is planned after completion of this pregnancy. |
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Authors:
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Jennifer R Diamond; Christina A Finlayson; Christiane Thienelt; Peter Kabos; Laura Hardesty; Linda Barbour; Catherine E Klein; Rachel Rabinovitch; Anthony Elias; Virginia F Borges |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Oncology (Williston Park, N.Y.) Volume: 23 ISSN: 0890-9091 ISO Abbreviation: Oncology (Williston Park, N.Y.) Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-09-25 Completed Date: 2009-10-16 Revised Date: 2010-08-31 |
Medline Journal Info:
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Nlm Unique ID: 8712059 Medline TA: Oncology (Williston Park) Country: United States |
Other Details:
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Languages: eng Pagination: 784-91 Citation Subset: IM |
Affiliation:
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Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use BRCA2 Protein / genetics* Breast Neoplasms / diagnosis*, drug therapy, genetics Cyclophosphamide / administration & dosage Doxorubicin / administration & dosage Female Humans Infant, Newborn Lymph Node Excision Male Mastectomy, Segmental Pregnancy Pregnancy Complications, Neoplastic / diagnosis*, drug therapy, genetics Pregnancy Trimester, First Pregnancy Trimester, Second Prognosis Thrombophilia / complications, diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/BLID protein, human; 0/BRCA2 Protein; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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