Document Detail


Early-stage BRCA2-linked breast cancer diagnosed in the first trimester of pregnancy associated with a hypercoagulable state.
MedLine Citation:
PMID:  19777765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This patient was found to have a BRCA2 gene mutation. She underwent lumpectomy and axillary lymph node dissection without any evidence of lymph node metastasis. Systemic chemotherapy with doxorubicin and cyclophosphamide for four cycles was administered beginning in the second trimester. She was treated with prophylactic LMWH until delivery and then for 6 weeks postpartum. She delivered a healthy baby boy and, after a period of breast-feeding, underwent bilateral mastectomy with immediate reconstruction. She remains well and is expecting her second child. Prophylactic oophorectomy is planned after completion of this pregnancy.
Authors:
Jennifer R Diamond; Christina A Finlayson; Christiane Thienelt; Peter Kabos; Laura Hardesty; Linda Barbour; Catherine E Klein; Rachel Rabinovitch; Anthony Elias; Virginia F Borges
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Oncology (Williston Park, N.Y.)     Volume:  23     ISSN:  0890-9091     ISO Abbreviation:  Oncology (Williston Park, N.Y.)     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2009-10-16     Revised Date:  2010-08-31    
Medline Journal Info:
Nlm Unique ID:  8712059     Medline TA:  Oncology (Williston Park)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  784-91     Citation Subset:  IM    
Affiliation:
Division of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
BRCA2 Protein / genetics*
Breast Neoplasms / diagnosis*,  drug therapy,  genetics
Cyclophosphamide / administration & dosage
Doxorubicin / administration & dosage
Female
Humans
Infant, Newborn
Lymph Node Excision
Male
Mastectomy, Segmental
Pregnancy
Pregnancy Complications, Neoplastic / diagnosis*,  drug therapy,  genetics
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prognosis
Thrombophilia / complications,  diagnosis*
Chemical
Reg. No./Substance:
0/BLID protein, human; 0/BRCA2 Protein; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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