Document Detail

Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury.
MedLine Citation:
PMID:  22846945     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Established acute respiratory distress syndrome (ARDS) is often refractory to treatment. Clinical trials have demonstrated modest treatment effects, and mortality remains high. Ventilator strategies must be developed to prevent ARDS.
HYPOTHESIS: Early ventilatory intervention will block progression to ARDS if the ventilator mode (1) maintains alveolar stability and (2) reduces pulmonary edema formation.
METHODS: Yorkshire pigs (38-45 kg) were anesthetized and subjected to a "two-hit" ischemia-reperfusion and peritoneal sepsis. After injury, animals were randomized into two groups: early preventative ventilation (airway pressure release ventilation [APRV]) versus nonpreventative ventilation (NPV) and followed for 48 hours. All animals received anesthesia, antibiotics, and fluid or vasopressor therapy as per the Surviving Sepsis Campaign. Titrated for optimal alveolar stability were the following ventilation parameters: (1) NPV group--tidal volume, 10 mL/kg + positive end-expiratory pressure - 5 cm/H2O volume-cycled mode; (2) APRV group--tidal volume, 10 to 15 mL/kg; high pressure, low pressure, time duration of inspiration (Thigh), and time duration of release phase (Tlow). Physiological data and plasma were collected throughout the 48-hour study period, followed by BAL and necropsy.
RESULTS: APRV prevented the development of ARDS (p < 0.001 vs. NPV) by PaO₂/FIO₂ ratio. Quantitative histological scoring showed that APRV prevented lung tissue injury (p < 0.001 vs. NPV). Bronchoalveolar lavage fluid showed that APRV lowered total protein and interleukin 6 while preserving surfactant proteins A and B (p < 0.05 vs. NPV). APRV significantly lowered lung water (p < 0.001 vs. NPV). Plasma interleukin 6 concentrations were similar between groups.
CONCLUSION: Early preventative mechanical ventilation with APRV blocked ARDS development, preserved surfactant proteins, and reduced pulmonary inflammation and edema despite systemic inflammation similar to NPV. These data suggest that early preventative ventilation strategies stabilizing alveoli and reducing pulmonary edema can attenuate ARDS after ischemia-reperfusion and sepsis.
Shreyas Roy; Benjamin Sadowitz; Penny Andrews; Louis A Gatto; William Marx; Lin Ge; Guirong Wang; Xin Lin; David A Dean; Michael Kuhn; Auyon Ghosh; Joshua Satalin; Kathy Snyder; Yoram Vodovotz; Gary Nieman; Nader Habashi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of trauma and acute care surgery     Volume:  73     ISSN:  2163-0763     ISO Abbreviation:  J Trauma Acute Care Surg     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-31     Completed Date:  2012-10-18     Revised Date:  2013-09-25    
Medline Journal Info:
Nlm Unique ID:  101570622     Medline TA:  J Trauma Acute Care Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-400     Citation Subset:  AIM; IM    
Cardiopulmonary & Critical Care Laboratory, Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA.
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MeSH Terms
Biopsy, Needle
Bronchoalveolar Lavage Fluid
Disease Models, Animal
Hemodynamics / physiology
Lung Injury / mortality,  prevention & control*,  therapy
Positive-Pressure Respiration / methods
Pulmonary Gas Exchange
Pulmonary Ventilation*
Random Allocation
Respiration, Artificial / methods*
Respiratory Distress Syndrome, Adult / prevention & control*
Respiratory Mechanics
Sensitivity and Specificity
Survival Rate
Tidal Volume
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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