| Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo. | |
| | |
MedLine Citation:
|
PMID: 10079233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The generation of sensory and autonomic neurons from the neural crest requires the functions of two classes of basic helix-loop-helix (bHLH) transcription factors, the Neurogenins (NGNs) and MASH-1, respectively (Fode, C., Gradwohl, G., Morin, X., Dierich, A., LeMeur, M., Goridis, C. and Guillemot, F. (1998) Neuron 20, 483-494; Guillemot, F., Lo, L.-C., Johnson, J. E., Auerbach, A., Anderson, D. J. and Joyner, A. L. (1993) Cell 75, 463-476; Ma, Q., Chen, Z. F., Barrantes, I. B., de la Pompa, J. L. and Anderson, D. J. (1998 Neuron 20, 469-482). We have cloned two chick NGNs and found that they are expressed in a subset of neural crest cells early in their migration. Ectopic expression of the NGNs in vivo biases migrating neural crest cells to localize in the sensory ganglia, and induces the expression of sensory neuron-appropriate markers in non-sensory crest derivatives. Surprisingly, the NGNs can also induce the expression of multiple pan-neuronal and sensory-specific markers in the dermomyotome, a mesodermal derivative. Taken together, these data suggest that a subset of neural crest cells may already be specified for a sensory neuron fate early in migration, as a consequence of NGN expression. |
| | |
Authors:
|
S E Perez; S Rebelo; D J Anderson |
Related Documents
:
|
12514223 - Signaling by bone morphogenetic proteins and smad1 modulates the postnatal differentiat... 9857963 - A novel drosophila paired-like homeobox gene related to caenorhabditis elegans unc-4 is... 16775783 - Cry1aa lacks stability elements at its 5'-utr but integrity of its transcription termin... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Development (Cambridge, England) Volume: 126 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 1999 Apr |
Date Detail:
|
Created Date: 1999-06-01 Completed Date: 1999-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8701744 Medline TA: Development Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1715-28 Citation Subset: IM |
Affiliation:
|
Division of Biology 216-76 and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GENBANK/AF123884; AF123885 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Animals Base Sequence Basic Helix-Loop-Helix Transcription Factors Biological Markers Cell Differentiation Chick Embryo DNA, Complementary Ganglia Gene Expression Regulation, Developmental Helix-Loop-Helix Motifs* Mice Molecular Sequence Data Nerve Tissue Proteins / genetics, metabolism* Neural Crest Neurons, Afferent / cytology* Sequence Homology, Amino Acid Spinal Nerve Roots Transcription Factors / genetics, metabolism* Xenopus Proteins* |
| Chemical | |
Reg. No./Substance:
|
0/Basic Helix-Loop-Helix Transcription Factors; 0/Biological Markers; 0/DNA, Complementary; 0/Nerve Tissue Proteins; 0/Transcription Factors; 0/Xenopus Proteins; 0/neurogenin, Xenopus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
Next Document: Spatially regulated SpEts4 transcription factor activity along the sea urchin embryo animal-vegetal ...