Document Detail

Early serum interleukin-8 evaluation may prove useful in localizing abnormally implanted human gestations after in vitro fertilization.
MedLine Citation:
PMID:  18249366     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether early measurement of the serum cytokines interleukin-2 receptor (IL-2R), IL-6, and IL-8 along with human chorionic gonadotropin (hCG) and progesterone (P(4)) can differentiate an ectopic from an intrauterine gestation. DESIGN: Retrospective analysis. SETTING: University-based fertility center. PATIENT(S): 75 women who underwent treatment with in vitro fertilization (IVF) and subsequently had an ectopic gestation (n = 15), spontaneous abortion (SAB) (n = 30), or term delivery (TD) (n = 30). INTERVENTION(S): Serum samples were obtained 14 (day 28) and 21 (day 35) days after oocyte retrieval. MAIN OUTCOME MEASURE(S): Serum concentrations of IL-2R, IL-6, IL-8, P(4), and hCG. RESULT(S): Median hCG readings on day 28 and day 35 were statistically significantly lower in the ectopic gestation group than in those with spontaneous abortion or term delivery. On day 28, median IL-8 levels were lower in the ectopic gestation group when compared with all intrauterine gestations combined. No statistically significant differences in IL-2R or IL-6 levels were noted between groups. Despite P(4) supplementation, median day-35 P(4) levels were lower in ectopic gestation than in the spontaneous abortion and term delivery cycles. CONCLUSION(S): In the setting of a rise or plateau in hCG levels, low day-28 IL-8 and day-35 P(4) levels suggested an extrauterine implantation. This assay combination may facilitate earlier diagnosis of an ectopic gestation when pregnancy location is unclear.
Sara S Morelli; Debbra A Keegan; Lewis C Krey; Joseph Katz; Mengling Liu; Nicole Noyes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-04
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2008-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2068-72     Citation Subset:  IM    
New York University Fertility Center, New York University School of Medicine, New York, New York 10016, USA.
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MeSH Terms
Abortion, Spontaneous / blood
Biological Markers / blood
Chorionic Gonadotropin / blood
Embryo Implantation*
Fertilization in Vitro*
Gestational Age
Interleukin-6 / blood
Interleukin-8 / blood*
Live Birth
Predictive Value of Tests
Pregnancy Outcome
Pregnancy, Ectopic / blood*,  diagnosis
Progesterone / blood
Receptors, Interleukin-2 / blood
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/IL6 protein, human; 0/IL8 protein, human; 0/Interleukin-6; 0/Interleukin-8; 0/Receptors, Interleukin-2; 57-83-0/Progesterone

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