| Early seizures after severe closed head injury. | |
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MedLine Citation:
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PMID: 9043746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We studied the incidence and clinical significance of early post-traumatic seizures after severe closed head injury. METHODS: This prospective study is based on clinical observation of 3340 adult patients with severe closed head injuries, each of them having a Glasgow Coma Scale (GCS) 3 to 8 after trauma. Anticonvulsant agents were not given to these patients unless there was evidence of seizure. RESULTS: One hundred and twenty-one patients (3.6%) experienced seizures within 1 week after head injury; 42 of these (1.26% of the series) had seizures within 24 hours after trauma. The incidence of intracerebral parenchymal damage was found to be higher among those patients who developed seizures in the first week (66.1%) than in those who did not (62.7%). However this result did not reach statistical significance. The patients with early seizures had a lower mortality rate (p < 0.01). In patients who survived from the initial injury, the occurrence of early post-traumatic seizures did not appear to influence the neurological recovery at 6 months after injury. CONCLUSION: Presence of intracerebral parenchymal damage on CT scan after severe closed head injury does not increase the risk of early post-traumatic seizures. With proper treatment, patients presenting with early seizures may have a lower mortality rate. However, the occurrence of early seizures does not influence the neurological recovery in patients who survive the initial severe closed head injury. |
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Authors:
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S T Lee; T N Lui; C W Wong; Y S Yeh; W C Tzuan; T Y Chen; S Y Hung; C T Wu |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 24 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-05-14 Completed Date: 1997-05-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: CANADA |
Other Details:
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Languages: eng Pagination: 40-3 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anticonvulsants / therapeutic use Female Glasgow Coma Scale Head Injuries, Closed / complications*, radiography Humans Male Middle Aged Prospective Studies Risk Factors Seizures / drug therapy, epidemiology, etiology* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
| Comments/Corrections | |
Comment In:
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Can J Neurol Sci. 1997 Nov;24(4):359-60
[PMID:
9398986
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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