Document Detail

Early results with composite strut caged ball prostheses.
MedLine Citation:
PMID:  7416015     Owner:  NLM     Status:  MEDLINE    
The Starr-Edwards model 6400/10 mitral and 2400/10 aortic valve prostheses incorporate metallic tracks on the inner aspects of cloth-covered struts in an attempt to preserve the favorable thromboembolic performance of cloth-covered valves while avoiding the risk of cloth wear. Two hundred severity operative survivors of mitral valve replacement with the model 6400/10 prosthesis, all on continuous anticoagulant therapy, have been followed up for a mean period of 2.3 (maximal 6) years. The late survival rate is 91 percent and the removal-free rate is 94 percent at 5 years. The rate of embolism (mean +/- standard error of the mean) is 4.6 +/- 0.9 percent per patient-year. Significant bleeding complications occurred at a rate of 1.0 +/- 0.2 percent per patient-year; there were no deaths. Two hundred forty operative survivors of aortic valve replacement with a model 2400/10 prosthesis, all on continuous anticoagulant therapy, have been followed up for a mean of 2.0 (maximal 7) years. The 5 year survival rate is 84 percent and the removal-free rate is 98 percent. Embolism occurred at a rate of 3.3 +/- 0.8 percnet per patient-year. Hemorrhagic complications occurred at a rate of 2.1 +/- 0.6 percent per patient-year; there were three families. Cloth wear and hemolysis have not been significant problems with this prosthesis, and the rates of thromboembolism are comparable with those reported for xenograft bioprostheses. The composite strut (track) valve prosthesis is a durable alternative to tissue valves in patients who are able to tolerate anticoagulant therapy.
Q Macmanus; G Grunkemeier; L Housman; C Maloney; B Harlan; L Lambert; A Starr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  46     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  566-9     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Valve*
Heart Valve Prosthesis* / adverse effects
Middle Aged
Mitral Valve*
Thromboembolism / etiology
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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