Document Detail

Early results of a single-blinded, randomized, controlled, Internet-based multicenter trial comparing Prolene and Vypro II mesh in Lichtenstein hernioplasty.
MedLine Citation:
PMID:  14648244     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The standard polypropylene mesh used in Lichtenstein's operation induces a strong foreign-tissue reaction with potentially harmful effects. A mesh with less polypropylene could possibly be beneficial. PATIENTS AND METHODS: Six hundred men with inguinal hernias were randomized to Lichtenstein's operation with Prolene or Vypro II in a single-blinded multicenter trial. The randomization was performed by a computer algorithm in a database through the Internet. All data were entered and directly validated in the database through the Internet. RESULTS: The meshes had comparable results in return to work, return to daily activities, complications, postoperative pain, and quality of life during the first 8 weeks of rehabilitation. CONCLUSIONS: Lichtenstein's operation with either Prolene or Vypro II is safe and well tolerated with an acceptable postoperative rehabilitation time and a high quality of life 2 months after surgery. The study was facilitated by the use of a database through the Internet.
Sven Bringman; Timo-Jaakko Heikkinen; Staffan Wollert; Johanna Osterberg; Sam Smedberg; Håkan Granlund; Stig Ramel; Göran Felländer; Bo Anderberg
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2003-11-26
Journal Detail:
Title:  Hernia : the journal of hernias and abdominal wall surgery     Volume:  8     ISSN:  1265-4906     ISO Abbreviation:  Hernia     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-26     Completed Date:  2004-08-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9715168     Medline TA:  Hernia     Country:  France    
Other Details:
Languages:  eng     Pagination:  127-34     Citation Subset:  IM    
Center For Surgical Sciences, K53 Karolinska Institutet at Huddinge University Hospital, 141 86, Stockholm, Sweden.
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MeSH Terms
Hernia, Inguinal / surgery*
Middle Aged
Polyglactin 910*
Postoperative Complications
Quality of Life
Randomized Controlled Trials as Topic / methods
Single-Blind Method
Surgical Mesh*
Reg. No./Substance:
0/Polypropylenes; 34346-01-5/Polyglactin 910

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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