Document Detail

Early results of endovascular treatment of the thoracic aorta using the Valiant endograft.
MedLine Citation:
PMID:  17710474     Owner:  NLM     Status:  MEDLINE    
Endovascular repair of the thoracic aorta has been adopted as the first-line therapy for much pathology. Initial results from the early-generation endografts have highlighted the potential of this technique. Newer-generation endografts have now been introduced into clinical practice and careful assessment of their performance should be mandatory. This study describes the initial experience with the Valiant endograft and makes comparisons with similar series documenting previous-generation endografts. Data were retrospectively collected on 180 patients treated with the Valiant endograft at seven European centers between March 2005 and October 2006. The patient cohort consisted of 66 patients with thoracic aneurysms, 22 with thoracoabdominal aneurysms, 19 with an acute aortic syndrome, 52 with aneurysmal degeneration of a chronic dissection, and 21 patients with traumatic aortic transection. The overall 30-day mortality for the series was 7.2%, with a stroke rate of 3.8% and a paraplegia rate of 3.3%. Subgroup analysis demonstrated that mortality differed significantly between different indications; thoracic aneurysms (6.1%), thoracoabdominal aneurysms (27.3%), acute aortic syndrome (10.5%), chronic dissections (1.9%), and acute transections (0%). Adjunctive surgical procedures were required in 63 patients, and 51% of patients had grafts deployed proximal to the left subclavian artery. Comparison with a series of earlier-generation grafts demonstrated a significant increase in complexity of procedure as assessed by graft implantation site, number of grafts and patient comorbidity. The data demonstrate acceptable results for a new-generation endograft in series of patients with diverse thoracic aortic pathology. Comparison of clinical outcomes between different endografts poses considerable challenges due to differing case complexity.
Matt Thompson; Stella Ivaz; Nicholas Cheshire; Rosella Fattori; Herve Rousseau; Robin Heijmen; Jean-Paul Beregi; Frederic Thony; Gillian Horne; Robert Morgan; Ian Loftus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-21
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  30     ISSN:  0174-1551     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1130-8     Citation Subset:  IM    
St George's Vascular Institute, 4th Floor St James Wing, St George's Hospital NHS Trust, Blackshaw Road, London SW17 0QT, UK.
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MeSH Terms
Aorta, Thoracic*
Aortic Diseases / pathology,  therapy*
Blood Vessel Prosthesis*
Blood Vessel Prosthesis Implantation
Middle Aged
Prosthesis Design
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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