Document Detail

Early restoration of cocaine-induced splanchnic hypoperfusion in anesthetized dogs.
MedLine Citation:
PMID:  17972217     Owner:  NLM     Status:  MEDLINE    
Although cardiovascular effects of cocaine have been well studied, little is known about its effects on splanchnic perfusion. We studied systemic and regional hemodynamic effects of acute cocaine intoxication in dogs under volatile anesthesia. Mechanically ventilated beagle dogs, randomized at 1.5% halothane (n = 7) or 2.25% sevoflurane (n = 7) anesthesia, received an intravenous bolus of cocaine (12 mg/kg over 5 min) followed by 0.22 mg/kg/min infusion over 30 min. They were observed for 60 min thereafter. Cardiac index (CI), heart rate (HR), mean arterial pressure (MAP), portal blood flow (PBF), gastric PCO(2) (gas tonometry), blood gases, and lactate and cocaine levels were assessed. Cocaine bolus promoted significant reductions in CI (~50%), HR (~20%), MAP (~20%), and PBF (~50%), accompanied by increase in systemic and splanchnic oxygen extractions and in gastric mucosal-arterial PCO(2) gradient. Those changes were maintained during cocaine infusion and returned to baseline values parallel to plasmatic cocaine clearance. Unlike other shock states, regional parameters, including gastric mucosal-arterial PCO(2) gradient, were restored before systemic variables. A possible local vasodilatory effect of volatile agents could play a role in this phenomenon. Cocaine infusion in anesthetized animals promoted marked systemic and regional hemodynamic derangement, which was rapidly reversible with decay of cocaine plasmatic concentration.
Marcos Batista Reis; Alejandra Del Pilar Gallardo Garrido; Ruy Jorge Cruz; Edson Augusto Ribeiro; Mauricio Rocha E Silva; Luiz Francisco Poli de Figueiredo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  20     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-10-31     Completed Date:  2007-12-06     Revised Date:  2010-03-10    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-9     Citation Subset:  IM    
Research Division, Heart Institute (InCor), University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Cocaine / blood,  pharmacology*
Halothane / pharmacology
Heart Rate / drug effects
Splanchnic Circulation / drug effects*
Reg. No./Substance:
151-67-7/Halothane; 50-36-2/Cocaine

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