| Early respiratory course in infants with cystic fibrosis: relevance to newborn screening. | |
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MedLine Citation:
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PMID: 1782128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Respiratory morbidity and mortality during infancy are important problems in the care of CF patients whether they are diagnosed conventionally or through newborn screening. Although the mechanisms of lung disease in CF remain to be elucidated, two potential pathophysiologic mechanisms--viral infection and undernutrition--can be associated with respiratory morbidity in infancy. Colonization of some infants with Pseudomonas and the presence of early mucus casts and cytokines in bronchoalveolar lavage suggest that pathophysiologic processes that are important in later life may begin in infancy. The early respiratory abnormalities, morbidity and mortality seen in CF indicate the need for future investigations of the respiratory course and interventional trials in infancy. |
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Authors:
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F J Accurso; R J Sokol; K B Hammond; S H Abman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Pediatric pulmonology. Supplement Volume: 7 ISSN: 1054-187X ISO Abbreviation: Pediatr Pulmonol Suppl Publication Date: 1991 |
Date Detail:
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Created Date: 1992-03-13 Completed Date: 1992-03-13 Revised Date: 2008-02-26 |
Medline Journal Info:
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Nlm Unique ID: 9014095 Medline TA: Pediatr Pulmonol Suppl Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 42-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Colorado School of Medicine, Denver. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cystic Fibrosis
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complications*,
prevention & control* Humans Infant Infant, Newborn Lung / physiopathology* Lung Diseases / etiology* Neonatal Screening* Respiration / physiology Respiratory Function Tests |
| Grant Support | |
ID/Acronym/Agency:
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MCJ-080508-03//PHS HHS; RR00069/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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