Document Detail


Early respiratory course in infants with cystic fibrosis: relevance to newborn screening.
MedLine Citation:
PMID:  1782128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Respiratory morbidity and mortality during infancy are important problems in the care of CF patients whether they are diagnosed conventionally or through newborn screening. Although the mechanisms of lung disease in CF remain to be elucidated, two potential pathophysiologic mechanisms--viral infection and undernutrition--can be associated with respiratory morbidity in infancy. Colonization of some infants with Pseudomonas and the presence of early mucus casts and cytokines in bronchoalveolar lavage suggest that pathophysiologic processes that are important in later life may begin in infancy. The early respiratory abnormalities, morbidity and mortality seen in CF indicate the need for future investigations of the respiratory course and interventional trials in infancy.
Authors:
F J Accurso; R J Sokol; K B Hammond; S H Abman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pediatric pulmonology. Supplement     Volume:  7     ISSN:  1054-187X     ISO Abbreviation:  Pediatr Pulmonol Suppl     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-13     Completed Date:  1992-03-13     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  9014095     Medline TA:  Pediatr Pulmonol Suppl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Colorado School of Medicine, Denver.
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MeSH Terms
Descriptor/Qualifier:
Cystic Fibrosis / complications*,  prevention & control*
Humans
Infant
Infant, Newborn
Lung / physiopathology*
Lung Diseases / etiology*
Neonatal Screening*
Respiration / physiology
Respiratory Function Tests
Grant Support
ID/Acronym/Agency:
MCJ-080508-03//PHS HHS; RR00069/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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