Document Detail

Early repolarization variant: epidemiological aspects, mechanism, and differential diagnosis.
MedLine Citation:
PMID:  18651379     Owner:  NLM     Status:  MEDLINE    
Early repolarization variant (ERV or ERPV) is a enigmatic electrocardiographic phenomenon, characterized by prominent J wave and ST-segment elevation in multiple leads. Recently, there has been renewed interest in ERV because of similarities to the arrhythmogenic Brugada syndrome (BrS). Not much is known about the epidemiology of ERV and several studies have reported that this condition is associated with a good prognosis. Both syndromes exhibit some similarities including the ionic underlying mechanism, the analogous responses to changes in heart rate and autonomic tone, sympathicomimetics (isoproterenol test) as well as in sodium channel and beta-blockers. These observations raise the hypothesis that ERV may be not as benign as traditionally believed. Additionally, there are documents showing that ST-segment height in the man is greatly influenced by central sympathetic nervous activity, both at baseline and during physiologic and pharmacological stress. Central sympathetic dysfunction regularly results in multilead ST-segment elevation or J wave that decreases or below isoelectric baseline during low dose isoproterenol infusion. In this review, we describe the characteristics of ERV and the main differences with acute pericarditis, acute myocardial infraction/injury and Brugada syndrome.
Andrés Ricardo Pérez Riera; Augusto Hiroshi Uchida; Edgardo Schapachnik; Sérgio Dubner; Li Zhang; Celso Ferreira Filho; Celso Ferreira
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology journal     Volume:  15     ISSN:  1897-5593     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-24     Completed Date:  2008-10-21     Revised Date:  2008-10-22    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  4-16     Citation Subset:  IM    
Electro-Vectorcardigraphic Section, ABC Medical School, ABC Foundation, Santo André, São Paulo, Brazil.
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MeSH Terms
Brugada Syndrome / diagnosis*,  epidemiology,  physiopathology*
Diagnosis, Differential
Heart Conduction System / physiopathology*
Myocardial Infarction / diagnosis*,  epidemiology,  physiopathology
Pericarditis / diagnosis*,  epidemiology,  physiopathology
Sympathetic Nervous System / physiopathology
Comment In:
Cardiol J. 2008;15(2):203; author reply 204-5   [PMID:  18651409 ]

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