Document Detail

Early repolarization patterns and the role of additional proarrhythmic triggers.
MedLine Citation:
PMID:  23275475     Owner:  NLM     Status:  Publisher    
The majority of individuals with early repolarization (ER) patterns have a benign prognosis. However, recent case-control series and population studies have established a significant association between ER and an increased risk of arrhythmic death. There is a common agreement that J-waves, particularly of large amplitude, dynamic, and present in multiple leads, are more prevalent in patients with idiopathic ventricular fibrillation, but the distinction between benign and malignant electrocardiographic variants of ER is still a controversial subject. Some authors have proposed the increased dispersion of repolarization or delayed fragmented depolarization in individuals with J-waves would place them at increased arrhythmic risk, but only in the presence of additional proarrhythmic factors or triggers. The scientific community has therefore embraced research for the identification of those proarrhythmic triggers that could unmask the malignant nature of certain ER variants. This manuscript aims at reviewing very recently published data relating ER patterns and sudden cardiac death in the presence of additional proarrhythmic triggers, in particular acute myocardial ischaemia, focusing on possible pathophysiological and electrogenic mechanisms and therapeutic implications.
Sérgio Barra; Rui Providência; Luís Paiva; José Nascimento
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-28
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  -     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cardiology Department, Coimbra's Hospital and University Centre, Quinta dos Vales, 3041-801 S. Martinho do Bispo, Coimbra, Portugal.
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