Document Detail

Early reperfusion strategies after acute ST-segment elevation myocardial infarction: the importance of timing.
MedLine Citation:
PMID:  16265339     Owner:  NLM     Status:  MEDLINE    
Acute ST-segment elevation myocardial infarction is estimated to occur in more than 500,000 people in the US every year. With the introduction of reperfusion therapy by fibrinolysis or primary angioplasty, mortality has significantly fallen. Although fibrinolysis is more readily available than primary angioplasty, the latter is more effective and results in better short-term and long-term outcomes if performed in a timely manner by an experienced operator and hospital team. The ischemic time, door-to-balloon time and clinical risk are important determinants of favorable outcome. Primary angioplasty is the preferred reperfusion strategy when symptom onset is longer than 3 h, in high-risk patients, such as those with cardiogenic shock, congestive heart failure or elderly age, and those with contraindications for fibrinolysis. Primary angioplasty is the preferred strategy in interventional facilities, with a goal door-to-balloon time of less than 90 min. For patients who present to noninterventional facilities, transfer to a hospital capable of primary angioplasty is safe and effective if the additional treatment delay is less than 90 min. Facilitated percutaneous coronary intervention has been shown in several small trials to offer early vessel patency and improve outcomes compared with fibrinolysis alone, but has not been shown to reduce mortality. Larger trials are ongoing to evaluate the benefit of this approach. The establishment of an effective and efficient system for the rapid transport of patients to centers capable and experienced in primary angioplasty is severely needed to provide optimum treatment and outcomes to patients with ST-segment elevation acute myocardial infarction.
David P Faxon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature clinical practice. Cardiovascular medicine     Volume:  2     ISSN:  1743-4297     ISO Abbreviation:  -     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2005-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226507     Medline TA:  Nat Clin Pract Cardiovasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  22-8     Citation Subset:  IM    
Section of Cardiology, University of Chicago, IL 60637, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Myocardial Infarction / physiopathology,  therapy*
Myocardial Reperfusion*
Thrombolytic Therapy
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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