| Early regional changes of GFAP mRNA in rat hippocampus and dentate gyrus during soman-induced seizures. | |
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MedLine Citation:
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PMID: 8742489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the time course of GFAP levels in the hippocampal formation during the first 24 h following soman intoxication in rats. GFAP mRNA expression was detected by in situ hybridization. Intense GFAP mRNA expression was present in the molecular layer of the dentate gyrus as early as 6 h after intoxication. This expression was comparatively lower in other dentate gyrus layers and hippocampal CA1, CA3 and CA4 areas and seemed to be related to excessive neuronal activity. Histopathological examination demonstrated that GFAP expression in dentate gyrus is not correlated with lesions. The high astrocytic reactivity in the molecular layer of the dentate gyrus is discussed in relation to the maintenance of the homeostasis of glutamate and of synaptic plasticity in this area during soman intoxication. |
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Authors:
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V Baille-Le Crom; J M Collombet; P Carpentier; G Brochier; M F Burckhart; A Foquin; I Pernot-Marino; G Rondouin; G Lallement |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 7 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-10-17 Completed Date: 1996-10-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 365-9 Citation Subset: IM |
Affiliation:
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Unite de Neurotoxicologie, Centre de Recherches du Service de Santé des Armées, La Tronche, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / drug effects Base Sequence Dentate Gyrus / metabolism*, pathology Glial Fibrillary Acidic Protein / genetics* Hippocampus / metabolism*, pathology Male Molecular Sequence Data Nerve Tissue Proteins / genetics* RNA, Messenger / metabolism* Rats Rats, Wistar Seizures / chemically induced, metabolism* Soman |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein; 0/Nerve Tissue Proteins; 0/RNA, Messenger; 96-64-0/Soman |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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