| Early recanalization rate of major occluded brain arteries after intravenous tissue plasminogen activator therapy using serial magnetic resonance angiography studies. | |
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MedLine Citation:
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PMID: 19713704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The present study investigated early recanalization rate of major occluded arteries after tissue plasminogen activator (t-PA) infusion using serial magnetic resonance angiography (MRA) studies. METHODS: Consecutive stroke patients treated with t-PA within 3 h of onset were prospectively studied. Four serial MRA studies were conducted: before, immediately, 24 h and 5-7 days after t-PA infusion. RESULTS: Initial MRA demonstrated occluded brain arteries in 64 patients: M1 occlusion, 30 patients; M2, 12, and internal carotid artery (ICA), 22. Combining M1 and M2 occlusion, the recanalization rates (complete and partial) were 52.3% (19.0 and 33.3%) within 1 h, 80.9% (47.6 and 33.3%) at 24 h and 87.8% (73.2 and 14.6%) 7 days after t-PA infusion. However, the recanalization rate of ICA occlusion was 31.8% (4.5 and 27.3%) within 1 h, 51.1% (14.3 and 47.6%) at 24 h and 66.7% (38.9 and 27.8%) 7 days after t-PA infusion. Complete recanalization rate at 24 h and 7 days was lower in ICA occlusion than M1 and M2 occlusion (p = 0.014 and p = 0.016). CONCLUSION: Within 1 h after t-PA infusion, approximately half the patients with major arteries occlusion had early recanalization. ICA occlusion is resistant to intravenous t-PA therapy compared with middle cerebral artery occlusion. |
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Authors:
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Kazumi Kimura; Yasuyuki Iguchi; Kensaku Shibazaki; Junya Aoki; Junichi Uemura |
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Publication Detail:
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Type: Journal Article Date: 2009-08-27 |
Journal Detail:
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Title: European neurology Volume: 62 ISSN: 1421-9913 ISO Abbreviation: Eur. Neurol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-09 Completed Date: 2009-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 287-92 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan. kimurak@med.kawasaki-m.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Arterial Occlusive Diseases / drug therapy*, pathology Brain Ischemia / drug therapy*, pathology Cerebral Arteries / drug effects*, pathology Female Humans Magnetic Resonance Angiography Male Patient Selection Prognosis Prospective Studies Time Factors Tissue Plasminogen Activator / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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