Document Detail

Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome.
MedLine Citation:
PMID:  16615955     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if postnatal growth failure exerts an adverse effect on subsequent growth and neurodevelopment. STUDY DESIGN: A secondary analysis of 1018 infants who were enrolled in a randomized, clinical trial of glutamine supplementation was performed to determine whether early provision of parenteral amino acids (AA) is associated with better growth and neurodevelopmental outcomes. Infants were stratified by whether they were provided > or =3 g/kg per day of AA at < or =5 days of life (early; n = 182) or not (late; n = 836). RESULTS: At 36 weeks' postmenstrual age, significant differences were found in weight, length, and head circumference in favor of the infants who received early AA; the odds of having weight less than the 10(th) percentile for age was 4-fold higher for infants in the late group. At 18 months' CA, there were no differences in weight, length, or measures of neurodevelopment between the groups; however, male infants in the late group were twice as likely to have head circumference less than the 10(th) percentile. CONCLUSIONS: Early AA were associated with significantly better growth outcomes at 36 weeks' postmenstrual age, and fewer infants who received early AA were found to have suboptimal head growth at 18 months' CA.
Brenda B Poindexter; John C Langer; Anna M Dusick; Richard A Ehrenkranz;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  148     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  300-305     Citation Subset:  AIM; IM    
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, 46202, USA.
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MeSH Terms
Body Height
Body Weight
Child Development*
Dietary Supplements
Double-Blind Method
Drug Administration Schedule
Glutamine / administration & dosage*
Infant, Newborn
Infant, Very Low Birth Weight / growth & development*
Infusions, Parenteral
Sex Characteristics
Reg. No./Substance:
Comment In:
J Pediatr. 2006 Mar;148(3):291-4   [PMID:  16615952 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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