| Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome. | |
| | |
MedLine Citation:
|
PMID: 16615955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine if postnatal growth failure exerts an adverse effect on subsequent growth and neurodevelopment. STUDY DESIGN: A secondary analysis of 1018 infants who were enrolled in a randomized, clinical trial of glutamine supplementation was performed to determine whether early provision of parenteral amino acids (AA) is associated with better growth and neurodevelopmental outcomes. Infants were stratified by whether they were provided > or =3 g/kg per day of AA at < or =5 days of life (early; n = 182) or not (late; n = 836). RESULTS: At 36 weeks' postmenstrual age, significant differences were found in weight, length, and head circumference in favor of the infants who received early AA; the odds of having weight less than the 10(th) percentile for age was 4-fold higher for infants in the late group. At 18 months' CA, there were no differences in weight, length, or measures of neurodevelopment between the groups; however, male infants in the late group were twice as likely to have head circumference less than the 10(th) percentile. CONCLUSIONS: Early AA were associated with significantly better growth outcomes at 36 weeks' postmenstrual age, and fewer infants who received early AA were found to have suboptimal head growth at 18 months' CA. |
| | |
Authors:
|
Brenda B Poindexter; John C Langer; Anna M Dusick; Richard A Ehrenkranz; |
Related Documents
:
|
17171675 - Limb growth in captive galago senegalensis: getting in shape to be an adult. 2599595 - Intra-uterine growth curves for midarm and thigh circumferences. 12801105 - The centers for disease control and prevention 2000 growth charts and the growth of bre... 370385 - Neurologic sequelae in infants with intrauterine growth retardation. 8034765 - Neuropsychologic function in same-sex twins discordant for perinatal brain damage. 23023555 - Racial and ethnic disparities in infant mortality in the united states: the role of ges... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 148 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-04-17 Completed Date: 2006-05-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 300-305 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, 46202, USA. bpoindex@iupui.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Body Height Body Weight Cephalometry Child Development* Dietary Supplements Double-Blind Method Drug Administration Schedule Female Glutamine / administration & dosage* Humans Infant Infant, Newborn Infant, Very Low Birth Weight / growth & development* Infusions, Parenteral Male Sex Characteristics |
| Chemical | |
Reg. No./Substance:
|
56-85-9/Glutamine |
| Comments/Corrections | |
Comment In:
|
J Pediatr. 2006 Mar;148(3):291-4
[PMID:
16615952
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multicentric malignant Schwannoma in a crossbred cow.
Next Document: Pilot study of milrinone for low systemic blood flow in very preterm infants.