Document Detail

Early progesterone cessation after in vitro fertilization/intracytoplasmic sperm injection: a randomized, controlled trial.
MedLine Citation:
PMID:  22749223     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To investigate the effect of stopping progesterone (P) support at week 5 versus week 8 on ongoing pregnancy rate after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). DESIGN: Prospective, randomized, controlled trial. SETTING: University-affiliated infertility center. PATIENT(S): A total of 220 patients with intrauterine pregnancy demonstrated by transvaginal ultrasound after IVF/ICSI. INTERVENTION(S): Luteal phase support with micronized vaginal P was suspended at week 5 or at week 8. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate, miscarriage rate, and number of bleeding episodes. RESULT(S): Progesterone levels were similar on the day of the first pregnancy ultrasound exam (149 ± 108 vs. 167 ± 115 ng/mL). Significantly more bleeding episodes were observed in the first trimester in the group with early cessation of P supplementation (18.0 ± 2.6 vs. 7.2 ± 1.3 episodes). Miscarriage rates among singleton pregnancies were similar in the two groups (5/80 vs. 6/79). CONCLUSION(S): Vaginal P supplementation after IVF/ICSI can be safely withdrawn at 5 weeks' gestation, because cycle outcome was similar to conventional luteal phase support up to 8 weeks of pregnancy. CLINICAL TRIAL REGISTRATION NUMBER: NCT01177904.
Graciela Kohls; Francisco Ruiz; María Martínez; Erik Hauzman; Gabriel de la Fuente; Antonio Pellicer; Juan A Garcia-Velasco
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
IVI Madrid, Madrid, Spain.
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