Document Detail

Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection.
MedLine Citation:
PMID:  25210168     Owner:  NLM     Status:  Publisher    
IMPORTANCE: Broadly neutralizing antibodies (bNAbs) are developed by HIV-1-infected subjects, but so far (and despite intensive efforts over the past three decades) have not been elicited by immunization. Understanding how bNAbs are generated during natural HIV-1 infection and why only some HIV-1-infected subjects generate such antibodies, will assist our efforts to elicit bNAbs by immunization. CXCR5+ PD-1+ CD4+ T cells are critical for the development of high affinity antigen-specific antibody responses. In our study, we found that not only did the HIV-1-infected subjects who develop bNAbs have a higher frequency of peripheral CXCR5+ PD-1+ CD4+ T cells in early infection, but also that this frequency mirrored what was observed in uninfected subjects and correlated with the level of B cell activation across subjects. Our study highlight the critical role helper T cell function has in the elicitation of broadly neutralizing antibody responses in the context of HIV- infection.
Kristen Cohen; Marcus Altfeld; Galit Alter; Leonidas Stamatatos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-10
Journal Detail:
Title:  Journal of virology     Volume:  -     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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