Document Detail

Early pregnancy failure induced by dibutyltin dichloride in mice.
MedLine Citation:
PMID:  17295259     Owner:  NLM     Status:  MEDLINE    
In this study, we examined the adverse effects of dibutyltin on initiation and maintenance of pregnancy after maternal administration during early pregnancy in mice. Following successful mating, female ICR mice were given dibutyltin dichloride (DBTCl) at 0, 7.6, 15.2, or 30.4 mg/kg bw/day by gastric intubation on days 0-3 or days 4-7 of pregnancy. Female mice were sacrificed on day 18 of pregnancy, and the pregnancy outcome was determined. After administration of DBTCl on days 0-3, the rate of nonpregnant females and the incidence of preimplantation embryonic loss were significantly increased at 30.4 mg/kg bw/day. The incidences of postimplantation embryonic loss in females given DBTCl on days 0-3 at 15.2 mg/kg and higher and on days 4-7 at 7.6 mg/kg bw/day and higher were increased. No increase in the incidence of fetuses with external malformations was observed after the administration of DBTCl on days 0-3 or days 4-7. A decline in the serum progesterone levels was detected in mice given DBTCl at 30.4 mg/kg bw/day on days 0-3 or days 4-7 of pregnancy. The data show that DBTCl adversely affects the initiation and maintenance of pregnancy when administered during early pregnancy in mice and suggest that the decline in serum progesterone levels is responsible for pregnancy failure.
Makoto Ema; Sakiko Fujii; Tsuguo Ikka; Mariko Matsumoto; Akihiko Hirose; Eiichi Kamata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental toxicology     Volume:  22     ISSN:  1520-4081     ISO Abbreviation:  Environ. Toxicol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-28     Completed Date:  2007-05-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100885357     Medline TA:  Environ Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  IM    
Division of Risk Assessment, Biological Safety Center, National Institute of Health Sciences, Tokyo 185-8501, Japan.
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MeSH Terms
Dose-Response Relationship, Drug
Embryo Loss / chemically induced*
Immunosuppressive Agents / toxicity*
Mice, Inbred ICR
Organotin Compounds / administration & dosage,  toxicity*
Pregnancy Maintenance / drug effects*
Pregnancy Trimester, First
Pregnancy, Animal / drug effects*
Progesterone / blood
Time Factors
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Organotin Compounds; 57-83-0/Progesterone; 683-18-1/dibutyldichlorotin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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