| Early pregnancy failure: factors affecting successful medical treatment. | |
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MedLine Citation:
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PMID: 20928983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The results of medical treatment for early pregnancy failure are conflicting. OBJECTIVES: To determine whether gestational sac volume measurement as well as other variables can predict the success rate of medical treatment for early pregnancy failure. METHODS: The study group comprised 81 women diagnosed with missed abortion or anembryonic pregnancy who consented to medical treatment. Demographic data were collected and beta-human chorionic gonadotropin level was documented. Crown-rump length and the sac volume were measured using transvaginal ultrasound. TVU was performed 12-24 hours after intravaginal administration of 800 micro g misoprostol. If the thickness of the uterine cavity was less than 30 mm, the women were discharged. If the sac was still intact or the thickness of the uterine cavity exceeded 30 mm, they were offered an additional dosage of intravaginal misoprostol or surgical uterine evacuation. RESULTS: Medical treatment successfully terminated 32 pregnancies (39.5%), 30 after one dose of misoprostol and 2 after two doses (group A); 49 underwent surgical evacuation (group B), 47 following one dose of misoprostol and 2 following two doses. There were no significant differences between the groups in age and gestational week. Gestational sac volume did not differ between groups A and B (10.03 and 11.98 ml respectively, P = 0.283). Parity (0.87 and 1.43, P = 0.015), previous pregnancies (2.38 and 2.88, P = 0.037), and betahCG concentration (6961 and 28,748 mlU, P = 0.013) differed significantly between the groups. CONCLUSIONS: Gestational sac volume is not a predictor of successful medical treatment for early pregnancy failure. Previous pregnancies and deliveries and higher betahCG concentration negatively affect the success rate of medical treatment. |
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Authors:
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Marwan Odeh; Rene Tendler; Mohamad Kais; Olga Maximovsky; Ella Ophir; Jacob Bornstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Israel Medical Association journal : IMAJ Volume: 12 ISSN: 1565-1088 ISO Abbreviation: Isr. Med. Assoc. J. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-10-08 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100930740 Medline TA: Isr Med Assoc J Country: Israel |
Other Details:
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Languages: eng Pagination: 325-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Western Galilee Hospital, Nahariya, affiliated with Rappaport Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel. marwan20@bezeqint.net |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage* Abortion, Missed / blood, drug therapy*, surgery, ultrasonography Adolescent Adult Chorionic Gonadotropin, beta Subunit, Human / blood Female Humans Misoprostol / administration & dosage* Pregnancy Ultrasonography, Prenatal Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Chorionic Gonadotropin, beta Subunit, Human; 59122-46-2/Misoprostol |
| Comments/Corrections | |
Comment In:
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Isr Med Assoc J. 2010 Jun;12(6):375-6
[PMID:
20928994
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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