Document Detail

Early pregnancy failure: beware of the pitfalls of modern management.
MedLine Citation:
PMID:  23084007     Owner:  NLM     Status:  MEDLINE    
The evolution of the diagnosis and management of women with an early pregnancy loss has been a success story. The mortality from ectopic pregnancy has objectively been decreased in the past few decades. However, modern management has resulted in a new set of issues. Over-interpretation of a single ultrasound, misunderstanding of the utility of serial hCG values, and inappropriate use of methotrexate can result in iatrogenic complications. Modern management has successfully improved the diagnosis of ectopic pregnancy before rupture; it should now also focus on ensuring that an intrauterine pregnancy is not interrupted as a result of diagnosis and treatment. This article reviews some of the pitfalls of the modern management of early pregnancy failure and introduces a series of articles on the subject.
Kurt T Barnhart
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review; Video-Audio Media    
Journal Detail:
Title:  Fertility and sterility     Volume:  98     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-01-03     Revised Date:  2014-01-20    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1061-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / adverse effects
Abortion, Spontaneous / blood,  diagnosis*,  mortality,  therapy*,  ultrasonography
Abortion, Therapeutic* / adverse effects,  methods
Biological Markers / blood
Chorionic Gonadotropin / blood
Diagnosis, Differential
Diagnostic Errors
Early Diagnosis
Methotrexate / adverse effects
Predictive Value of Tests
Pregnancy Outcome
Pregnancy, Ectopic / blood,  diagnosis*,  mortality,  therapy*,  ultrasonography
Prenatal Diagnosis* / methods
Risk Assessment
Risk Factors
Treatment Outcome
Ultrasonography, Prenatal
Unnecessary Procedures
Grant Support
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Biological Markers; 0/Chorionic Gonadotropin; YL5FZ2Y5U1/Methotrexate

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