| Early pregnancy failure: beware of the pitfalls of modern management. | |
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MedLine Citation:
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PMID: 23084007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The evolution of the diagnosis and management of women with an early pregnancy loss has been a success story. The mortality from ectopic pregnancy has objectively been decreased in the past few decades. However, modern management has resulted in a new set of issues. Over-interpretation of a single ultrasound, misunderstanding of the utility of serial hCG values, and inappropriate use of methotrexate can result in iatrogenic complications. Modern management has successfully improved the diagnosis of ectopic pregnancy before rupture; it should now also focus on ensuring that an intrauterine pregnancy is not interrupted as a result of diagnosis and treatment. This article reviews some of the pitfalls of the modern management of early pregnancy failure and introduces a series of articles on the subject. |
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Authors:
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Kurt T Barnhart |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review; Video-Audio Media |
Journal Detail:
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Title: Fertility and sterility Volume: 98 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-22 Completed Date: 2013-01-03 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1061-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Departments of Obstetrics and Gynecology and Epidemiology, Perelman School of Medicine at the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. kbarnhart@obgyn.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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adverse effects Abortion, Spontaneous / blood, diagnosis*, mortality, therapy*, ultrasonography Abortion, Therapeutic* / adverse effects, methods Biological Markers / blood Chorionic Gonadotropin / blood Diagnosis, Differential Diagnostic Errors Early Diagnosis Female Humans Methotrexate / adverse effects Predictive Value of Tests Pregnancy Pregnancy Outcome Pregnancy, Ectopic / blood, diagnosis*, mortality, therapy*, ultrasonography Prenatal Diagnosis* / methods Risk Assessment Risk Factors Treatment Outcome Ultrasonography, Prenatal Unnecessary Procedures |
| Grant Support | |
ID/Acronym/Agency:
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K24HD060687/HD/NICHD NIH HHS; R01 HD036455/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Biological Markers; 0/Chorionic Gonadotropin; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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