Document Detail


Early pregnancy factor suppresses experimental autoimmune encephalomyelitis induced in Lewis rats with myelin basic protein and in SJL/J mice with myelin proteolipid protein peptide 139-151.
MedLine Citation:
PMID:  11102634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Early pregnancy factor (EPF) is a secreted protein with immunosuppressive and growth factor properties. During pregnancy, it appears in maternal serum within 6-24 h of fertilization, is present for at least the first two-thirds of pregnancy in all species studied and is essential for embryonic survival. It is a homologue of chaperonin 10, a heat shock protein, but, unlike other members of this family, EPF has an extracellular role. As it has the ability to modulate CD4+ T cell-dependent immune responses, its role in treatment of experimental autoimmune encephalomyelitis (EAE) was investigated. EAE is a CD4+ T cell-mediated disease, the best available animal model of multiple sclerosis (MS). Two models of EAE were investigated, acute EAE induced in Lewis rats by inoculation with myelin basic protein (MBP-EAE) and chronic relapsing EAE induced in SJL/J mice by inoculation with myelin proteolipid protein peptide (residues 139-151) (PLP-EAE). EPF, delivered intraperitoneally or orally to rats or intraperitoneally to mice, suppressed clinical signs of disease. Mice with PLP-EAE were also treated with interferon-beta, with and without EPF. Both EPF and IFN-beta suppressed clinical signs of EAE and, when administered together, gave greater suppression than when given separately. These findings suggest that EPF may be a potential candidate for use in treatment of MS and may be of use in combined therapy with IFN-beta.
Authors:
B Zhang; J Harness; M J Somodevilla-Torres; N C Hillyard; A W Mould; D Alewood; S G Love; P F Alewood; J M Greer; A C Cavanagh; P A McCombe; H Morton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  182     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  5-15     Citation Subset:  IM    
Affiliation:
Department of Surgery, The University of Queensland, Royal Brisbane Hospital, 4029, Queensland, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology,  therapeutic use*
Animals
Chaperonin 10
Drug Evaluation, Preclinical
Encephalomyelitis, Autoimmune, Experimental / chemically induced,  drug therapy*,  immunology
Female
Immunosuppressive Agents / pharmacology,  therapeutic use*
Interferon-beta / pharmacology,  therapeutic use*
Lymphocyte Activation / drug effects,  immunology
Mice
Myelin Basic Proteins
Myelin Proteolipid Protein
Peptides / pharmacology,  therapeutic use*
Pregnancy
Pregnancy Proteins*
Rats
Rats, Inbred Lew
Suppressor Factors, Immunologic*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Chaperonin 10; 0/Immunosuppressive Agents; 0/Myelin Basic Proteins; 0/Myelin Proteolipid Protein; 0/Peptides; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 0/early pregnancy factor; 77238-31-4/Interferon-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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