Document Detail

Early pregnancy factor (EPF) as a marker for detecting subclinical embryonic loss in clomiphene citrate-treated women.
MedLine Citation:
PMID:  7576116     Owner:  NLM     Status:  MEDLINE    
PROBLEM: A discrepancy exists between the apparently normal ovulation and the pregnancy rates in women treated with clomiphene citrate (CC). Our previous studies have indicated that immuno-suppressive "early pregnancy factor" (EPF) is a novel marker to detect subclinical embryonic loss in infertile women. METHOD: In the present study EPF was used as a marker to detect subclinical embryonic loss in women treated with CC with/without gonadotropins. In some of the women treated with CC, conception was assisted by artificial insemination with husband's semen (AIH). RESULTS: Our results have indicated that fertilization occurred (EPF + ve) in 47.7% (52/109) of women treated with CC with/without gonadotropins; 13.46% (7/52) retained the fetus and continued pregnancy till full term, whereas 78.9% (41/52) did not retain the fetuses. In the group where after stimulation, conception was assisted by AIH, fertilization was observed in 38.24% (26/68), retention in 11.54% (3/26) but subclinical embryonic loss was observed in 80.8% (21/26) cases. CONCLUSION: Thus, our results have indicated that subclinical embryonic loss may account for some of the discrepancy observed between the apparently normal ovulation and the pregnancy rates in women treated with clomiphene citrate.
S K Shahani; C L Moniz; J S Gokral; P K Meherji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  33     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-12-04     Completed Date:  1995-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  350-3     Citation Subset:  IM    
Institute for Research in Reproduction, Bombay, India.
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MeSH Terms
Biological Markers / analysis
Chaperonin 10
Clomiphene / therapeutic use*
Fertility Agents, Female / therapeutic use*
Fetal Death / diagnosis*
Gonadotropins / therapeutic use
Immunosuppressive Agents / analysis*
Ovulation Induction
Peptides / analysis*
Pregnancy Proteins*
Single-Blind Method
Suppressor Factors, Immunologic*
Reg. No./Substance:
0/Biological Markers; 0/Chaperonin 10; 0/Fertility Agents, Female; 0/Gonadotropins; 0/Immunosuppressive Agents; 0/Peptides; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 0/early pregnancy factor; 911-45-5/Clomiphene

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