Document Detail

Early pregnancy diagnosis in goats by determination of pregnancy-associated glycoprotein concentrations in plasma samples.
MedLine Citation:
PMID:  10734369     Owner:  NLM     Status:  MEDLINE    
Different RIA systems available for measuring the concentrations of pregnancy-associated glycoproteins (PAGs) in dairy goats were compared in order to evaluate their accuracy in early pregnancy diagnosis. Plasma concentrations of PAGs were determined by 3 heterologous RIA systems with a bovine PAG standard and tracer in combination with antisera anti-ovine PAG (RIA 1), anti-caprine PAG55 + 62 (RIA 2), anti-caprine PAG55 + 59 (RIA 3), and by 2 homologous RIA systems that employed caprine PAG55 + 62 and caprine PAG55 + 59 and their specific antisera (RIAs 4 and 5, respectively). In all of the RIAs, the mean concentrations of PAGs were significantly higher (P < 0.01) in pregnant than in nonpregnant goats from Day 21 onwards after breeding. On Day 21, the accuracy rates of early pregnancy diagnoses were 56% (RIA 1), 96% (RIA 2), 99% (RIA 3), 95% (RIA 4) and 90% (RIA 5), whereas on Day 28 these rates were > 99% for RIAs 2, 3, 4 and 5. The RIAs for PAGs depend on proteins from the placenta being present in maternal plasma and require only a single sample of blood, to distinguish pregnant goats from those that fail to return to estrus for other reasons. The homologous and semi-heterologous assays are highly accurate as early as Day 21 of pregnancy.
F González; J Sulon; J M Garbayo; M Batista; F Cabrera; P Calero; A Gracia; J F Beckers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Theriogenology     Volume:  52     ISSN:  0093-691X     ISO Abbreviation:  Theriogenology     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-04-19     Completed Date:  2000-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421510     Medline TA:  Theriogenology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-25     Citation Subset:  IM    
Faculty of Veterinary, Las Palmas de Gran Canaria, Spain.
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MeSH Terms
Glycoproteins / blood
Pregnancy Proteins / blood*
Pregnancy Tests / methods,  veterinary*
Reproducibility of Results
Sensitivity and Specificity
Time Factors
Reg. No./Substance:
0/Glycoproteins; 0/Pregnancy Proteins

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