Document Detail


Early pregnancy blood lead and spontaneous abortion.
MedLine Citation:
PMID:  21170817     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Although evidence tends to suggest that high levels of lead exposure increase the risk of spontaneous abortion, we do not yet know whether moderate- to low-level exposure elevates risk. Among 351 women (aged 16 to 35 years, with single pregnancies) who were registered for a longitudinal study, 15 (4.3%) women experienced spontaneous abortion after the 12th week of gestation and before the 20th week. We collected participants' blood samples during the first trimester of pregnancy (8-12 weeks) for lead measurement by inductively coupled plasma-mass spectrometry. Mean ± standard deviation of blood lead was 3.8 ± 2.0 μg/dl (range 1.0-20.5 μg/dl) with a geometric mean of 3.5 μg/dl. Mean blood lead concentrations did not differ significantly between spontaneous abortion cases and ongoing pregnancies (3.51 ± 1.42 and 3.83 ± 1.99 μg/dl, respectively). The findings suggest that in apparently healthy women, low blood lead levels (mean < 5 μg/dl) measured in early pregnancy may not be a risk factor for spontaneous abortion.
Authors:
Mohsen Vigeh; Kazuhito Yokoyama; Fumihiko Kitamura; Mohammadreza Afshinrokh; Abootaleb Beygi; Shirin Niroomanesh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Women & health     Volume:  50     ISSN:  1541-0331     ISO Abbreviation:  Women Health     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608076     Medline TA:  Women Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  756-66     Citation Subset:  IM    
Affiliation:
Department of Hazard Assessment, National Institute of Occupational Safety and Health, Kawasaki, Japan. vigeh@h.jniosh.go.jp
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