Document Detail

Early pregnancy alters the metabolic responses to restricted nutrition in sheep.
MedLine Citation:
PMID:  18838244     Owner:  NLM     Status:  MEDLINE    
This study investigated whether a 27-day period of nutrition at half-maintenance during early pregnancy (up to Day 14) could alter maternal endocrine responses. Forty-six ewes were fed all or half of their maintenance requirements and slaughtered on Day 14 of the oestrous cycle or pregnancy. We used real time RT-PCR to study gene expression of growth hormone receptor (GHR) and leptin in adipose tissue and GHR, GHR1A and of the insulin-like growth factor I (IGF-I) in the liver. Blood profiles of metabolites and metabolic hormones were also determined. Throughout the experiment, underfed animals presented lower body weight and body condition, greater plasma concentrations of non-esterified fatty acids (NEFA), and lower plasma concentrations of leptin, compared to adequately fed animals. Undernutrition affected the patterns of gene expression in adipose and hepatic tissues, and the responses differed between pregnant and non-pregnant ewes. In adequately fed ewes, pregnancy up-regulated leptin mRNA expression in adipose tissue, a response that was impaired in underfed ewes. The hepatic expression of IGF-I mRNA was increased by pregnancy in underfed animals while no effect was observed in adequately fed ewes. It remains to be determined whether the changes in the endocrine milieu are paralleled by modifications in uterine gene expression that could alter the environment of the embryo during early pregnancy.
C Sosa; J A Abecia; M Carriquiry; F Forcada; G B Martin; I Palacín; A Meikle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-21
Journal Detail:
Title:  Domestic animal endocrinology     Volume:  36     ISSN:  1879-0054     ISO Abbreviation:  Domest. Anim. Endocrinol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505191     Medline TA:  Domest Anim Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-23     Citation Subset:  IM    
Department of Animal Production and Food Science, Veterinary Faculty, Miguel Servet 177, 50013 Zaragoza, Spain.
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MeSH Terms
Adipose Tissue / chemistry
Fatty Acids, Nonesterified / blood
Gene Expression
Gestational Age*
Insulin-Like Growth Factor I / genetics
Leptin / blood,  genetics
Liver / chemistry
Nutritional Requirements*
RNA, Messenger / analysis
Receptors, Somatotropin / genetics
Reverse Transcriptase Polymerase Chain Reaction
Sheep / metabolism*
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Leptin; 0/RNA, Messenger; 0/Receptors, Somatotropin; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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