Document Detail

Early predictors of intractability in childhood epilepsy: a community-based case-control study in Copparo, Italy.
MedLine Citation:
PMID:  10577265     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To identify early predictors of intractability in childhood and adolescence epilepsy. MATERIALS AND METHODS: We carried out a community-based case-control study using the incidence cohort of epileptic patients living in the district of Copparo, in the province of Ferrara, Italy. The comparative study was performed in 31 cases and 95 controls. Cases were patients who averaged at least 1 unprovoked seizure per month during an observational period of at least 2 years. Controls were subjects having achieved remission for at least 5 years regardless of current therapy. RESULTS: Onset at age <1 year, remote symptomatic etiology and high frequency of seizures before therapy were found to be independent early predictors of intractability. CONCLUSION: Our study suggested that the risk of developing intractable epilepsy may, to some extent, be predicted at the time of initial diagnosis in children with early-onset epilepsy of remote symptomatic etiology, especially if seizure propensity is initially high.
I Casetta; E Granieri; V C Monetti; G Gilli; M R Tola; E Paolino; V Govoni; E Iezzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  99     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-11-01     Completed Date:  1999-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  329-33     Citation Subset:  IM    
Dipartimento di Discipline Medico-Chirurgiche della Comunicazione e del Comportamento, Università di Ferrara, Italy.
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MeSH Terms
Age of Onset
Anticonvulsants / therapeutic use
Case-Control Studies
Child, Preschool
Disease Progression
Drug Resistance
Epilepsy / classification,  diagnosis,  drug therapy*,  epidemiology
Infant, Newborn
Italy / epidemiology
Risk Factors
Seizures / epidemiology
Statistics as Topic
Treatment Outcome
Reg. No./Substance:

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