Document Detail


Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy.
MedLine Citation:
PMID:  18443273     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Wilms' tumor gene WT1 is a reliable marker for minimal residual disease assessment in acute leukemia patients. The study was designed to demonstrate the potential use of WT1 to establish quality of remission in acute leukemia patients for early identification of patients at high risk of relapse. A prospective study based on a quantitative Real-Time PCR (TaqMan) assay in 562 peripheral blood samples collected from 82 acute leukemia patients at diagnosis and during follow-up was established. The evaluation of WT1 in peripheral blood samples after induction chemotherapy can distinguish the continuous complete remission patients from those who obtain only an "apparent" complete remission and who could relapse within a few months. WT1 helps identify patients at high risk of relapse soon after induction chemotherapy allowing post-induction therapy in high risk patients to be intensified.
Authors:
Daniela Cilloni; Francesca Messa; Francesca Arruga; Ilaria Defilippi; Enrico Gottardi; Milena Fava; Sonia Carturan; Renata Catalano; Enrico Bracco; Emanuela Messa; Paolo Nicoli; Daniela Diverio; Miguel A Sanz; Giovanni Martinelli; Francesco Lo-Coco; Giuseppe Saglio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-28
Journal Detail:
Title:  Haematologica     Volume:  93     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-02     Completed Date:  2008-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  921-4     Citation Subset:  IM    
Affiliation:
Dept. of Clinical and Biological Sciences of the University of Turin, San Luigi Hospital, Gonzole 10, 10043 Orbassano, Turin, Italy. daniela.cilloni@unito.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Agents / therapeutic use*
Gene Expression Profiling
Gene Expression Regulation, Neoplastic*
Genes, Wilms Tumor*
Humans
Leukemia, Myeloid, Acute / blood*,  diagnosis,  genetics,  therapy*
Middle Aged
Neoplasm Proteins / metabolism
Polymerase Chain Reaction
Prognosis
Recurrence
Risk
Treatment Outcome
WT1 Proteins / blood*,  physiology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Neoplasm Proteins; 0/WT1 Proteins

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