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Early prediction of nasal continuous positive airway pressure failure in preterm infants less than 30 weeks gestation.
MedLine Citation:
PMID:  22150698     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  To predict early nasal continuous positive airway pressure failure within the first 2 hours after birth in preterm infants. Methods:  Patient and respiratory support variables significantly associated with continuous positive airway pressure failure in the first 72 hours after birth were identified in a cohort of preterm infants < 30 weeks gestation. Using multivariable logistic regression analysis, risk estimates for early nasal continuous positive airway pressure failure were calculated. Results:  From 182 infants included 62(34%) failed early nasal continuous positive airway pressure. Birth weight ≤800 g, male gender and a fraction of inspired oxygen >0.25 at 1 and 2 hours of age were significantly associated with early nasal continuous positive airway pressure failure. Combining these variables in a logistic regression model provided a minimal risk estimate for failure of 0.04[0.01-0.23] (female >800 gram, FiO(2) ≤0.25 at 1, and 2 hours) and maximal estimate of 0.92[0.44-0.99] (male ≤800 gram, FiO(2) >0.25 at 1 and 2 hours). Conclusion:  Combining gender, birth weight and the fraction of inspired oxygen at 1 and 2 hours of age allows for a better and more individualized prediction of early nasal continuous positive airway pressure failure in preterm infants less than 30 weeks gestation.
Authors:
Anne P De Jaegere; Johanna H van der Lee; Caroline Canté; Anton H van Kaam
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-10
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Acta Paediatrica © 2011 Foundation Acta Paediatrica.
Affiliation:
Department of Neonatology Pediatric Clinical Epidemiology, Emma Children's Hospital AMC, Amsterdam, The Netherlands.
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