Document Detail

Early postoperative cognitive dysfunction and blood pressure during coronary artery bypass graft operation.
MedLine Citation:
PMID:  17562924     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the relationship between change in blood pressure during coronary artery bypass graft operations and early cognitive dysfunction. DESIGN: Cohort study. SETTING: Quaternary care facility. Patients Fifteen patients undergoing coronary artery bypass graft operations who were at high risk for postoperative stroke. Preoperative and intraoperative mean arterial pressures (MAPs) were measured in all patients. Intervention A subset of patients underwent preoperative and postoperative magnetic resonance imaging. Main Outcome Measure Change in cognitive performance, using the Mini-Mental State Examination and other simple cognitive tests. RESULTS: A drop in MAP (preoperatively to intraoperatively) predicted a decrease in Mini-Mental State Examination score. When change in MAP was dichotomized (after excluding an outlier), subjects with a small decrease improved on the Mini-Mental State Examination by 1 point, whereas those with a large drop in MAP worsened by 1.4 points (P = .04). CONCLUSION: A drop in MAP from a preoperative baseline may put patients at risk for early cognitive dysfunction after a coronary artery bypass graft operation.
Rebecca F Gottesman; Argye E Hillis; Maura A Grega; Louis M Borowicz; Ola A Selnes; William A Baumgartner; Guy M McKhann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-11
Journal Detail:
Title:  Archives of neurology     Volume:  64     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-09-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1111-4     Citation Subset:  AIM; IM    
Department of Neurology, Johns Hopkins University School of Medicine, Phipps 126, 600 N Wolfe St, Baltimore, MD 21287, USA.
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MeSH Terms
Aged, 80 and over
Blood Pressure*
Brain / pathology
Cognition Disorders / diagnosis,  etiology*
Cohort Studies
Coronary Artery Bypass / adverse effects*
Coronary Artery Disease / physiopathology*,  surgery*
Diffusion Magnetic Resonance Imaging
Follow-Up Studies
Intraoperative Period
Middle Aged
Preoperative Care
Psychological Tests
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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