Document Detail

Early postnatal nutrition and programming of the preterm neonate.
MedLine Citation:
PMID:  21294741     Owner:  NLM     Status:  In-Data-Review    
Early postnatal nutrition is a vital determinant of adult health; this is particularly true for the infant born prematurely and cared for in a hospital setting such as the neonatal intensive care unit. Human and animal studies support the contribution of postnatal dietary composition and the rate of extrauterine growth to long-term metabolic outcomes. One mechanism by which postnatal nutrition affects long-term outcome is via developmental programming. Programming, or the modulation of gene expression to impart a short-term advantage accompanied by a long-term cost, may be achieved by epigenetic modifications to chromatin. This review summarizes the details of postnatal nutritional content and rate of growth on the development of metabolic disease. The role of epigenetics in developmental programming of the preterm infant is also discussed, with an emphasis on animal models of dietary manipulation and directions in which the field must move in order to formulate effective feeding strategies for the preterm infant.
Julia E Wiedmeier; Lisa A Joss-Moore; Robert H Lane; Josef Neu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition reviews     Volume:  69     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  IM    
Copyright Information:
© 2011 International Life Sciences Institute.
Division of Neonatology, University of Utah, Salt Lake City, Utah, USA. Department of Pediatrics, University of Florida, Gainesville, Florida, USA.
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